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Expected Outcome:This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination “Tackling diseases and reducing disease burden”. To that end, proposals under this topic should aim to deliver results that are directed at, tailored towards and contributing to all the following expected outcomes:The EU is reinforced as an internationally recognised driver of research and innovation in Rare Diseases (RD) and thereby substantially contributing to the achievement of the Sustainable Development Goals related to rare diseases.Research funders align, adopt and implement their RD research policies allowing for the optimal generation and translation of knowledge into meaningful health products and interventions responding to the needs of people living with a rare disease across Europe and globally.The RD research community at large benef...

Expected Outcome:Proposals are expected to contribute to all the following expected outcomes:Strengthen the competitiveness, sustainability (including biodiversity) and resilience of an innovative clean tech solution by clearly demonstrating the capability to, significantly: increase its circular material use rate, based on a sound and realistic baseline; reduce the levelized cost of energy (LCOE) delivered to end-users - including, where relevant, production, distribution, and storage costs, based on a sound and realistic baseline and considering different geographic scenarios; and contribute to Europe’s industrial leadership and competitiveness, in line with the objectives of Net-Zero Industry Act (NZIA)[1] for the EU manufacturing capacity of net-zero technologies[2],[3]. Bring this innovative clean tech solution to full technological maturity and close to market-readiness with a view...

Expected Outcome:Proposals are expected to contribute to all the following expected outcomes:Accelerate the use of innovative technologies to decarbonise industrial processes and bring to the market more cost-effective clean products to strengthen the competitiveness, sustainability (including biodiversity), and resilience of EU industries;Create new innovative first-of-a-kind operational demonstrators and/or optimise newly installed industrial decarbonisation solutions in Europe; andDemonstrate the market readiness of the envisaged future clean products and their innovative processes via a credible business plan and an exploitation strategy for industrialisation, including market-tested use cases. Scope:The Clean Industrial Deal aims to secure the EU as an attractive location for manufacturing, including for energy-intensive industries, and to promote clean tech and new circular busines...

Expected Outcome:Proposals under this topic should aim to deliver results that are directed and tailored towards and contribute to all of the following expected outcomes:Patients with refractory cancers and their caregivers/families will have access to optimised, tailored and affordable immunotherapeutic interventions that increase their quality of life, across European regions, EU Member States and Associated Countries;Healthcare professionals and academia will have access to clinical evidence, on effectiveness of immunotherapeutic interventions, to deploy evidence-based treatment interventions with improved patient selection that improve outcomes in real life, i.e. in routine healthcare, for patients with refractory cancers who often present with co-morbidities;National healthcare providers, policymakers and authorities in European regions, EU Member States and Associated Countries wil...

Expected Outcome:Proposals under this topic should aim to deliver results that are directed and tailored towards and contribute to the following expected outcomes:Improved understanding of care needs of older patients with cancer and approaches to address them;Older cancer patients gain access to innovative age-specific approaches and tools better tailored to their care needs;National healthcare providers, policymakers and authorities in European regions, EU Member States and Associated Countries have the evidence to implement tailored care for older cancer patients that have the potential to be implemented in routine treatment and follow-up care in their healthcare systems; Scope:This topic contributes to the EU Cancer Mission’s objective to improve quality of life of cancer patients. The focus is on cancer patients aged 65 years and above.Currently, older cancer patients represent the...

Expected Outcome:Proposals under this topic should aim to deliver results that are directed and tailored towards and contribute to the following expected outcomes:Through the European Cancer Patient Digital Centre (ECPDC), adolescent and young cancer patients and survivors as well as their caregivers have access to innovative tools and approaches to strengthen their mental health;Healthcare professionals have access to innovative tools to monitor and support the mental health of cancer patients and survivors as well as their caregiversResearchers and healthcare professionals have access and use reliable patient reported data to better understand the mental health needs of cancer patients and survivors and provide effective care. Scope:As part of its citizens engagement activities, the EU Cancer Mission has launched a dialogue with young cancer survivors, to better understand the specific...

Expected Outcome:Proposals under this topic should aim to deliver results that are directed and tailored towards and contribute to all of the following expected outcomes:Healthy people and in particular people at risk will benefit from microbiome tests and programmes that can discover and predict their transition to cancer before the onset of disease.People will have a better understanding of risks and will be enabled to address risks early by following treatments or adapting their lifestyles, including nutrition and other interventions.Physicians will be able to start cancer treatments earlier with a higher success rate.Policy makers and authorities will be enabled to develop and implement advanced and strategic programmes addressing cancer prevention. Scope:This topic will contribute to the achievement of the EU Cancer Mission’s objective to achieve better cancer prevention and early d...

Expected Outcome:This topic aims to develop a wide capacity building programme between EU Member States/Associated Countries and Ukrainian cancer centres, to support improvement or development of research & innovation-related capacities and integration with cancer care.To this end, proposals should aim at delivering results that are directed and tailored towards and contribute to all of the following expected outcomes:Researchers, clinicians and health care professionals will have access to improved research capacities, supporting better integration with care.Patients and citizens will have access to improved screening, diagnostics and treatments, while increasing their participation in clinical trials. Scope:Ukraine has a very high cancer burden with more than 155,000 new diagnoses every year[1]. The country has also one of the highest childhood cancer mortality rates globally[2]. Dispa...

Expected Outcome:Proposals under this topic should aim to deliver results that are directed and tailored towards and contribute to all of the following expected outcomes:Researchers of different disciplines use advanced multiscale Virtual Human Twins (VHTs) to expand the knowledge and understanding of cancer onset and progressionHealthcare professionals and researchers have access to advanced VHT-based solutions that model cancer onset and progression over time, contributing to improve personalised treatmentsResearchers, healthcare professionals, innovators and citizens have access to cancer VHTs through the UNCAN.eu and the advanced Virtual Human Twin platforms Scope:Virtual human twins (VHTs) are digital representations and in-silico models of an individual’s health and disease at different levels of the human anatomy (e.g. cells, tissues, organs or organ systems) for the prevention, p...

Expected Outcome:Proposals under this topic should aim to deliver results that are directed and tailored towards and contribute to all of the following expected outcomes:Patients will benefit from better access to earlier, more person-centred palliative care models including digital remote tools and options for home-based care.Carers will benefit from real-time information tools and better communication.Clinicians will benefit from guidelines on optimal patient referral and care predictions. Scope:This topic will contribute to the achievement of the EU Cancer Mission’s objective to provide better quality of life for cancer patients, their families and carers. The focus is on the development of innovative models for earlier, more precise and better integrated palliative care.According to an EU conference on innovative palliative care for people with cancer on 8 October 2024[1], palliative...

Expected Outcome:Proposals are expected to contribute to one or more of the following:Robust AI models and systems capable of resisting different classes of adversarial manipulation;Innovative defence mechanisms for AI models and systems against new attack families;Methodologies for detecting and mitigating attacks, such as data poisoning, backdoor exploitation and misclassification;AI systems leveraging privacy-enhancing technologies that maintain data confidentiality and regulatory compliance, enabling trusted in-house AI deployments (e.g., for governments and enterprises). Scope:The increasing reliance on AI in cybersecurity, critical infrastructure, and decision-making processes raises concerns about the security and robustness of AI systems. As AI systems become more prevalent, they are increasingly targeted by adversarial attacks that manipulate inputs, compromise training data, or...

Expected Outcome:Proposals are expected to contribute to one or more of the following:Quantum-resistant cryptographic primitives, also other than lattice-based approaches if relevant, that enhance the security and privacy of digital wallets, both for natural persons and wallets, as well as the design and implementation of post-quantum solutions for entity authentication and authenticated key establishment over insecure networks;Formal verification tools, improved High-Assurance Cryptographic Software (HACS) approaches and their integration in software workflows, to provide strong security guarantees in post-quantum migration, and enable streamlined evidence-based evaluation of secure systems that use cryptography. Scope:The development of new digital signatures and advanced cryptographic schemes, tailored specifically to the use cases and requirements in the context of wallets/eIDs, for...

Expected Outcome:Proposals are expected to contribute to one or more of the following:Enhanced security frameworks for both hardware and software supply chains, building on root-of-trust architectures and secure lifecycle management;Secure and trusted chip architectures for next-generation computing and networking systems;Integrated security-by-design approaches in software development, aimed to be aligned with relevant regulatory requirements;Security testing methodologies, including formal verification approaches and AI-driven security testing methodologies;Standardised methodologies for hardware security assessment, also contributing to cybersecurity certification. Scope:The increasing complexity and globalisation of software and hardware supply chains introduce new vulnerabilities that cyber adversaries can exploit. Ensuring the security of both software and hardware components acros...

Expected Outcome:Project results are expected to complement and expand the outcomes of HORIZON-EURATOM-2024-NRT-01-02 by contributing to the following:Design and implement an action for establishing a European Nuclear Skills Academy, unifying the strategic direction and promoting standardised curricula across all qualification levels (from vocational to academic), thereby contributing to a more coordinated, EU-wide response to the skills shortage. The project will include a demonstration of recognition of learning outcomes and/or acquired skills between organisations in different Member States. Launch targeted training programmes, building on existing ones, specifically for critical areas such as Small Modular Reactors (SMRs) and advanced reactors. This includes building specialised expertise within national regulatory authorities for independent safety assessment of facilities and desig...

Objective:The Pericles IV programme has the following general objective:To prevent and combat counterfeiting and related fraud, preserve the integrity of the euro banknotes and coins, thus strengthening the trust of citizens and business in the genuineness of these banknotes and coins and therefore enhancing the trust in the Union's economy, while securing the sustainability of public finances.The Pericles IV programme has the following specific objective:To protect euro banknotes and coins against counterfeiting and related fraud, by supporting and supplementing the measures undertaken by the Member States and assisting the competent national and Union authorities in their efforts to develop among themselves and with the Commission a close and regular cooperation and an exchange of best practice, where appropriate including third countries and international organisations.

Expected Outcome:Project results are expected to contribute to all the following expected outcomes:Advance in the achievement of the Strategic Energy Technology (SET) Plan’s research and innovation priorities and targets for wind energy;Efficient and effective support to wind energy research and innovation through alignment and cooperation among different actors, avoiding fragmentation of efforts;Energy producers and consumers benefit from increased performance of wind energy technologies with the focus on efficiency and flexibility, reduced cost, improved reliability and sustainability, operation and maintenance, safety, robustness and security during all stages of the lifetime of a wind energy farm from installation, operation and maintenance to decommissioning;Increased contribution of wind energy to the energy system, with minimal impacts on health and the environment (notably biodiv...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:Better understanding of the factors and interdependencies that influence levels of renovation of rental properties in the affordable housing sector;Increased number of policy makers revise policies, regulations, instruments and business models to increase the rate of renovation of rental properties in the affordable housing sector. Scope:The Renovation Wave strategy sets out measures across the whole renovation chain that aim to increase the rate and depth of renovations. One of the key principles for housing renovation towards 2030 and 2050 is affordability, i.e. making energy efficient, comfortable, healthy, sustainable and climate-resilient buildings widely available, in particular for medium and lower-income households and vulnerable people and areas. A better understanding of the im...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:Based on the results of the project, at least one industrial sector with a significant heating demand in the EU and Associated Countries develops pathways and business models to measurably increase the recovery and upgrade of locally available heat for covering process needs and significantly or totally phasing out of fossil fuel use, while preserving or enhancing its global competitiveness.Measurable improvement of renewable and/or industrial excess/waste heat recovery and upgrade solutions, possibly combined with thermal and/or electrical energy storage, in terms of energy efficiency, flexibility of electrical demand, climate and environment protection, reliability and safety, physical and cyber security, and profitability. Scope:This topic aims to satisfy the need for process heat in...

Expected Outcome:Battery recycling is of strategic importance for both Europe and India, not only to keep raw materials in the respective territories but also to reduce the environmental impact of the recycling process. R&I in this area has been identified as a priority by the EU-India Trade and Technology Council’s Working Group on Green and Clean Energy Technology to reinforce bilateral cooperation.Project results are expected to contribute to all of the following expected outcomes:Battery recyclers based in the EU and India benefit from of the improved sustainability, safety, and affordability of innovative recycling processes.Stakeholders on battery recycling based in the EU and India benefit from each other’s experience on recycling logistics, including the informal processes and supply chain constraints.The cooperation between EU and India key researchers, institutions and industri...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:Increased number of building information tools, assessments and/or certificates makes use of digital data exchange platforms;More accurate and reliable EU-aligned life cycle inventories of embodied environmental flows in construction materials and products;Increased number of already existing building standards and certification schemes refer to GWP to support national decarbonisation strategies in line with relevant European legislation (such as Energy Performance of Buildings Directive, Construction Products Regulation and delegated acts, voluntary label for carbon footprint of steel, Delegated Act for carbon removal certification in long-lasting products);Improved data availability and interoperability for whole life carbon assessments across different building lifecycle stages. Scope...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:Measurable reduction in the costs of deep renovation compared to current best practices;Measurable increase in resource and energy efficiency compared to current best practices;Measurable reduction in the number of days when occupants are disturbed due to renovation works;Measurable reduction of dust, noise, waste and pollutant and greenhouse emissions on the construction site compared to current best practices. Scope:Meeting Europe’s ambition for the renovation of the housing stock requires innovative approaches that improve buildings’ energy performance and occupants’ satisfaction, at a reduced cost while speeding up the renovation process and minimising impact on the construction site and disturbance for occupants. Renovation approaches should cover the whole workflow from design, off...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:Increased evidence of factors such as physiological, behavioural, social, environmental and cultural that influence how different user and demographic groups perceive and use smart, secured, integrated energy efficient building systems, and how it affects the building whole-life cycle and energy savings, as well as occupant satisfaction, health and well-being;The design and operation of smart building systems and smart buildings are improved making them more user-friendly and effective. Scope:Significant investments have been made in developing hardware and software for smart buildings. There is still limited understanding how smart buildings solutions impact the energy performance of buildings and users’ comfort in practice. Research is required on the technical, social, and economic fa...

Expected Outcome:Proposals are expected to contribute to all following points:Significantly reduced EU dependency on imported battery-grade raw materials, specifically emerging technologies and carbon-based electrode materials.Established European value chains for next-generation battery materials, enhancing the EU's technological leadership and strategic autonomy. Scope:Proposals under this topic are expected to address all aspects for one of the following categories:1. Sustainable Processing and Refining of next generation batteries-grade Material, delivering all of the following:Development and validation of innovative, environmentally friendly refining technologies for producing battery-grade metals and materials suitable for next-generation battery chemistries. This covers raw and advanced electrode materials for the components of sodium-ion batteries or beyond generation 3[1] lithi...

Expected Outcome:The project results are expected to contribute to the following outcomes:support for the development of EU production of stable isotopes that are essential for the manufacturing of radionuclides used in novel nuclear medicine therapies;strengthening of the resilience and security of the EU medical radioisotope supply chain by securing access to source materials, reducing dependence on third countries and enhancing industrial-scale production (including the sourcing of stable isotopes);leveraging of the knowledge and expertise of nuclear scientists, physicists and engineers in order to develop and optimise the processes for the EU-based production of stable isotopes, while contributing to Europe’s Beating Cancer Plan and implementing the Strategic Agenda for Medical Ionising Radiation Applications (SAMIRA). Scope:Radiological and nuclear technologies are integral to moder...

Expected Outcome:The project results are expected to contribute to some of the following expected outcomes:research into safety of innovative reactors, small modular reactors (SMRs) – both light water SMRs (LW-SMRs) and Gen-IV-based advanced modular reactors (AMRs); design or demonstration of SMRs and fuel cycles’ viability; and efficient integration within low-carbon and smart energy systems;research support towards a shared and consistent approach among regulators’ TSOs to safety requirements for different advanced energy systems and applications (e.g. industrial heat, district heat and the maritime sector), supported by regular exchanges and reviews and workshops with licensees, SMR developers, and research organisations, thereby further improving safety across the EU;emphasis on innovation in the safety aspects of LW-SMRs and AMRs;establishment of operating rules for specific service...