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Although the majority living with schizophrenia and related disorders are over 35 years old, including those first diagnosed and those aging with the illness, the mechanisms underlying the generation and trajectory of the illness remain poorly understood. The purpose of this initiative is to advance translational research to better understand the emergence and trajectory of schizophrenia and related disorders in mid to late life, and to identity targets for future development of prevention and treatment efforts.

The goal of this Funding Opportunity Announcement (FOA) is to encourage applications for studies that will enhance knowledge of mechanisms associated with neuropsychiatric symptoms (NPS) in persons with Alzheimer's disease (AD) or Alzheimer's disease-related dementias (ADRD). The findings are expected to advance mechanistic understanding of both biobehavioral and neurobiological pathways leading to NPS. Findings may also provide insight into novel therapeutic targets that can be advanced into interventions to treat and prevent the development of NPS in AD and/or ADRD

The goal of this Funding Opportunity Announcement (FOA) is to encourage applications for studies that will enhance knowledge of mechanisms associated with neuropsychiatric symptoms (NPS) in persons with Alzheimer's disease (AD) or Alzheimer's disease-related dementias (ADRD). The findings are expected to advanceadavnce mechanistic understanding of both biobehavioral and neurobiologfical pathways leading to NPS. Findings may also provide insight into novel therapeutic targets that can be advanced into interventions to treat and prevent the development of NPS in AD and/or ADRD.

This Notice of Funding Opportunity (NOFO) encourages research on the biology of high-confidence risk factors associated with complex brain disorders, with a focus on the intracellular, transcellular, and circuit substrates of neural function. For the purposes of this NOFO, the term complex can refer to a multifactorial contribution to risk (e.g., polygenic and/or environmental) and/or highly distributed functional features of the brain disorder. Studies may be either hypothesis-generating (unbiased discovery) or hypothesis-testing in design and may utilize in vivo, in situ or in vitro experimental paradigms, e.g., model organisms or human cell-based assays. While behavioral paradigms and outcome measures can be incorporated into the research design to facilitate the characterization of intracellular, transcellular, and circuit mechanisms, these are neither required nor expected. Studies should not attempt to model disorders but instead should aim to elucidate the neurobiological impact of individual or combined risk factor(s), such as the affected molecular and cellular components and their relationships within defined biological process(es). This can include the fundamental biology of these factors, components, and processes. The resulting paradigms, component pathways, and biological processes should be disseminated with sufficient detail to enrich common and/or federated data resources (e.g., those contributing to the Gene Ontology, Synaptic Gene Ontology, FAIR Data Informatics) in order to bridge the gap between disease risk factors, biological mechanism and therapeutic...

This initiative seeks to solicit applications for research projects that address the link between social disconnection including both objective social isolation as well as perceived social isolation (otherwise known as loneliness) and suicide in late-life. Emphasis is placed on research that identifies neurobiological and environmental mechanisms associated with social isolation and loneliness that increase risk for suicidal thoughts and behavior in late-life, that uses an experimental therapeutics approach to identify targets and develop and test interventions to prevent late-life suicide, and that develops new and modifies existing service delivery models to enhance social connection in late-life to prevent suicide.

The National Institute on Alcohol Abuse and Alcoholism solicits applications for an R34 Clinical Trial Optional mechanism focusing on alcohol health services. This NOFO will broadly focus on closing the treatment gap for individuals with alcohol use disorder (AUD); within this focus, there are five major areas of emphasis: (1) increasing access to treatment for AUD, (2) making treatment for AUD more appealing, (3) examining cost structures and insurance systems, (4) conducting studies on dissemination and implementation of existing evidence-based approaches to treating AUD, and (5) reducing health disparities as a means of addressing the treatment gap in AUD for health disparity populations.

The National Institute on Alcohol Abuse and Alcoholism solicits applications for an R34 Clinical Trial Optional mechanism focusing on alcohol health services. This NOFO will broadly focus on closing the treatment gap for individuals with alcohol use disorder (AUD); within this focus, there are five major areas of emphasis: (1) increasing access to treatment for AUD, (2) making treatment for AUD more appealing, (3) examining cost structures and insurance systems, (4) conducting studies on dissemination and implementation of existing evidence-based approaches to treating AUD, and (5) reducing health disparities as a means of addressing the treatment gap in AUD for health disparity populations.

The National Institute on Alcohol Abuse and Alcoholism solicits applications for an R01 Clinical Trial Optional mechanism focusing on alcohol health services. This NOFO will broadly focus on closing the treatment gap for individuals with alcohol use disorder (AUD); within this focus, there are five major areas of emphasis: (1) increasing access to treatment for AUD, (2) making treatment for AUD more appealing, (3) examining cost structures and insurance systems, (4) conducting studies on dissemination and implementation of existing evidence-based approaches to treating AUD, and (5) reducing health disparities as a means of addressing the treatment gap in AUD for health disparity populations.

The National Institute on Alcohol Abuse and Alcoholism solicits applications for an R01 Clinical Trial Required mechanism focusing on alcohol treatment and recovery research. This NOFO will focus broadly on topics relevant for treatment of and recovery from alcohol use disorder (AUD), including: medications development, precision medicine, behavioral therapies and mechanisms of behavioral change (MOBC), recovery, translational research, and innovative methods and technologies for AUD treatment and recovery.

The goal of this NOFO is to support doctoral candidates from a variety of academic disciplines for up to two years for the completion of the doctoral dissertation research project. Research projects should align with NIDA funding priorities detailed here (https://www.drugabuse.gov/funding/funding-priorities). This award will facilitate the entry of promising new investigators into the field of substance use/substance use disorder (SU(D) research, enhancing the pool of highly talented SU(D) researchers.

                                                                                                Specific Procurement Notice                                                                                               Invitation for PrequalificationCountry: Kingdom of BhutanName of Project: Accelerating Transport and Trade Connectivity in Eastern South Asia (Access) – Bhutan ProjectContract Title: Construction of Gelephu-Tareythang Road and BridgesLoan No./Credit No./Grant No: IDA 77560 (Credit)/IDAE4310 (grant)Prequalification Reference No: ACCESS/DOST/WD-1, ACCESS/DOST/WD-2 and ACCESS/DOST/WD-31. The Royal Government of Bhutan has received financing from the World Bank toward the cost of the proposed Accelerating Transport and Trade Connectivity in Eastern South Asia (ACCESS) – Bhutan Project, and intends to apply part of the proceeds toward payments under the contracts for ACCESS/DOST/WD-1, ACCESS/DOST/WD-2, and ACCESS/DOST/WD-3 for the Construction of Gelephu-Tareythang Road and Bridges.2. The Department of Surface Transport (DoST), Ministry of Infrastructure and Transport (MoIT), Royal Government of Bhutan, intends to prequalify contractors for the following work packages unde...

                                                                                                Specific Procurement Notice                                                                                               Invitation for PrequalificationCountry: Kingdom of BhutanName of Project: Accelerating Transport and Trade Connectivity in Eastern South Asia (Access) – Bhutan ProjectContract Title: Construction of Gelephu-Tareythang Road and BridgesLoan No./Credit No./Grant No: IDA 77560 (Credit)/IDAE4310 (grant)Prequalification Reference No: ACCESS/DOST/WD-1, ACCESS/DOST/WD-2 and ACCESS/DOST/WD-31. The Royal Government of Bhutan has received financing from the World Bank toward the cost of the proposed Accelerating Transport and Trade Connectivity in Eastern South Asia (ACCESS) – Bhutan Project, and intends to apply part of the proceeds toward payments under the contracts for ACCESS/DOST/WD-1, ACCESS/DOST/WD-2, and ACCESS/DOST/WD-3 for the Construction of Gelephu-Tareythang Road and Bridges.2. The Department of Surface Transport (DoST), Ministry of Infrastructure and Transport (MoIT), Royal Government of Bhutan, intends to prequalify contractors for the following work packages unde...

                                                                                              Specific Procurement Notice                                                                                               Invitation for PrequalificationCountry: Kingdom of BhutanName of Project: Accelerating Transport and Trade Connectivity in Eastern South Asia (Access) – Bhutan ProjectContract Title: Construction of Gelephu-Tareythang Road and BridgesLoan No./Credit No./Grant No: IDA 77560 (Credit)/IDAE4310 (grant)Prequalification Reference No: ACCESS/DOST/WD-1, ACCESS/DOST/WD-2 and ACCESS/DOST/WD-31. The Royal Government of Bhutan has received financing from the World Bank toward the cost of the proposed Accelerating Transport and Trade Connectivity in Eastern South Asia (ACCESS) – Bhutan Project, and intends to apply part of the proceeds toward payments under the contracts for ACCESS/DOST/WD-1, ACCESS/DOST/WD-2, and ACCESS/DOST/WD-3 for the Construction of Gelephu-Tareythang Road and Bridges.2. The Department of Surface Transport (DoST), Ministry of Infrastructure and Transport (MoIT), Royal Government of Bhutan, intends to prequalify contractors for the following work packages under...

Request for BidsWorks(Two-envelope Bidding Process Without Prequalification)Employer: Ministry of Environmental Protection and Agriculture (MEPA)Project: Georgia Resilient Agriculture, Irrigation and Land Project (GRAIL)Contract title: Rehabilitation and Modernization of Zeda Arkhi Irrigation SchemeCountry: GeorgiaLoan No.: 9504-GERFB No: GR/W/RFB/02Issued on: July 20, 2026 The Government of Georgia has received financing from the World Bank toward the cost of the Georgia Resilient Agriculture and Irrigation Project and intends to apply part of the proceeds toward payments under the contract for Rehabilitation and Modernization of Zeda Arkhi Irrigation Scheme.The Ministry of Environmental Protection and Agriculture now invites sealed Bids from eligible Bidders for Rehabilitation and Modernization of Zeda Arkhi Irrigation Scheme. Namely, Rehabilitation and Modernization of Main Canal Structures: Sedimentation Basin, Animal Water Drinking Structures, Siphons, Canal Lining and Main Canal Outlets; Secondary, Tertiary, Lateral and Direct Pipeline Irrigation Network; and Complete SCADA Installation under the Zeda Arkhi Irrigation Scheme Located in Bolnisi Municipality, Kvemo Kartli, Geor...

INVITATION FOR BIDS Development and Implementation of a Fixed Broadband Quality of Service (QoS) and Quality of Experience (QoE) Monitoring System Country: MaldivesName of Project: Digital Maldives for Adaptation, Decentralization and Diversification (D’MADD) Project (P177040)Contract Title: Development and Implementation of a Fixed Broadband Quality of Service (QoS) and Quality of Experience (QoE) Monitoring SystemGrant No.: E047-MVRFB Reference No.: MV-MoECCT-DMADD-528841-GO-RFP The Government of the Republic of Maldives has received financing from the World Bank toward the cost of the Digital Maldives for Adaptation, Decentralization and Diversification(D’MADD) Project, and intends to apply part of the proceeds toward payments under the contract for Development and Implementation of a Fixed Broadband Quality of Service (QoS) and Quality of Experience (QoE) Monitoring System.The Ministry of Homeland Security, Labour and Technology now invites sealed Proposals from eligible Proposers for the procurement of Development and Implementation of a Fixed Broadband Quality of Service (QoS) and Quality of Experience (QoE) Monitoring System without the use of hardware probes, capable of mea...

MINISTERE DU DEVELOPPEMENT DE L’ENERGIE ET DES RESSOURCES HYDRAULIQUES **********DIRCTION DE CABINET**********Unité de Gestion des ProjetsPASEEL-PURACEL-PARSE**********Passation des Marchés N° …………./26/MDERH/DIRCAB/UGP/PM   REPUBLIQUE CENTRAFRICAINEUnité – Dignité – Travail**********                         Avis d’Appel d’Offres Equipements(Conception, Fourniture et Montage)(Processus à deux enveloppes, sans Préqualification)   Maître d’Ouvrage:Ministère du Développement de l’Energie et des Ressources Hydrauliques (MDERH) pour le compte de l’Energie Centrafricaine (ENERCA)Projet :Projet d’Accès et de Renforcement du Secteur de l’Electricité (PARSE – P176683)Intitulé du Marché :Fourniture et installation de Stockage supplémentaire à la Centrale solaire de SAKAI 1Pays:République CentrafricaineN° du Don :IDA No 0430N° Appel d’Offres:PARSE/074/GO/RFB/26Émis le :23 juillet 2026Le Gouvernement de la République Centrafricaine a reçu un financement de Banque Mondiale pour financer le Projet d’Accès et de Renforcement du Secteur de l’Electricité (PARSE – P176683), et à l’intention d’utiliser une partie de ce don pour effectuer des paiements au titre du marché fourniture et installation de s...

REQUEST FOR EXPRESSIONS OF INTEREST(INDIVIDUAL CONSULTANT)  Senior Waste Management Policy and Institutional Development Consultant                          Country: Sint MaartenProject: The Sint Maarten Emergency Debris Management ProjectAssignment Title: Senior Consultant-Waste Mng Policy and Institutional DevelopmentCredit/Loan no.: TF-B9747Reference no.: SX-NRPB-560450-CS-INDV The Government of Sint Maarten has received financing from the World Bank toward the cost of the Emergency Debris Management Project (EDMP) and intends to apply part of the proceeds for consulting services.The overall objective of the assignment is to engage a Senior Consultant to provide specialized technical and strategic expertise to support the implementation of activities aimed at strengthening the waste management sector. The Consultant will contribute to policy enhancement, capacity building and asset management within the Ministry of Public Housing, Spatial Planning, Environment and Infrastructure (VROMI) and other relevant government entities. The assignment will support ongoing operations and the establishment of a stronger institutional and policy framework for sustainable waste management and...

Buyer: AZIENDA USL DELLA ROMAGNA | Notice type: cn-standard | Procedure: open | Contract: services | Deadline: 2026-09-07

Buyer: Ruhrverband, Abteilung Zentrale Dienste, Einkauf | Notice type: cn-standard | Procedure: neg-w-call | Contract: services | Deadline: 2026-09-07

Buyer: Normandie Aménagement | Notice type: cn-standard | Procedure: open | Contract: services | Deadline: 2026-09-07

Buyer: Academisch Ziekenhuis Maastricht | Notice type: cn-standard | Procedure: open | Contract: supplies | Deadline: 2026-09-07

Buyer: Werkorganisatie BUCH | Notice type: cn-standard | Procedure: restricted | Contract: services | Deadline: 2026-09-07

Buyer: Ville de Reims | Notice type: cn-standard | Procedure: open | Contract: services | Deadline: 2026-09-07

Buyer: Gemeinde Hergensweiler | Notice type: cn-standard | Procedure: open | Contract: works | Deadline: 2026-09-07

Buyer: Parlamento Vasco - Parlamento Vasco | Notice type: cn-standard | Procedure: open | Contract: supplies | Deadline: 2026-09-07