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The U.S. Creative Tech Exchange (U.S.CTX) is a new international arts exchange program that drives economic growth by connecting U.S. creative professionals and technologists with international peers working at the intersection of the arts and emerging technologies, especially artificial intelligence (AI).  The goal is to position American technology as a key driver of American innovation, economic, and cultural influence in art and technology, For the purposes of this program, “arts” refers specifically to architecture, creative coding and gaming, fashion, graphic design, music and immersive art such as virtual reality (VR), augmented reality (AR), and mixed reality (MR); but excludes film and television.   U.S.CTX will support up to 30 participants through short-term, hands-on activities such as collaborative labs, fellowships, workshops, and public showcases.     ECA will award one U.S.-based nonprofit or educational organization $1.32 million to design and implement the program in close coordination with ECA and U.S. embassies. Applicants should propose a concept that leverages their strengths and includes clear plans for recruitment, program delivery, and measurable outcomes in creative arts, economic impact, and public diplomacy. Please see the Notice of Funding Opportunity for additional information.

The Office of Citizen Exchanges, Global Leaders Division, of the Bureau of Educational and Cultural Affairs (ECA) invites proposal submissions for the FY 2026 TechLeaders: Critical Emerging Technologies Program. TechLeaders will strengthen America’s technological edge and industry dominance by promoting U.S. leadership in Artificial Intelligence (AI), Space Technology, Biotechnology/Health Technology, Supply Chain/Cold Chain Technology, and Agricultural Technology (AgriTech).  This initiative engages approximately 60 foreign participants, ages 25-40, from Europe and Eurasia, East Asia and the Pacific, Middle East and North Africa, South and Central Asia, Sub-Saharan Africa, and the Western Hemisphere through a five-week intensive placement in the United States.  Participants will collaborate with U.S.-based mentors and companies to develop actionable solutions in critical technology sectors, showcasing American expertise and innovation. The program will also feature overseas components including reciprocal exchanges and an accelerator following the second U.S.-based cohort to expand U.S. influence, inspire future STEM professionals, and foster collaboration with American businesses.  TechLeaders supports U.S. national security and foreign policy objectives by exporting American expertise and technological innovations abroad, promoting U.S.-preferred technology standards globally, bolstering economic ties, and countering the proliferation of malign competitors’ technology in the global market. Organizations applying for this federal award must demonstrate the capacity to rec...

The U.S. Department of State’s Embassy Manila announces an open competition to implement a program to hold the Young Southeast Asian Leaders Initiative (YSEALI) Summit 2026 in Manila, Philippines. The in-person program advances U.S. strategic interests in the Indo-Pacific by promoting regional security, peace, and stability. By building awareness of and spurring action on regional security issues, including maritime, cyber, and energy security, the program will help advance a free and open Indo-Pacific for the combined one billion people of the United States and Southeast Asia. YSEALI is the flagship U.S. government initiative in Southeast Asia. Nearly 8,000 individuals have participated in YSEALI academic or professional fellowship exchanges, attended regional workshops, or implemented a small grant. Since 2016, the Department of State has convened competitively-selected YSEALI alumni for an annual summit to spur action around U.S. priorities. The successful applicant will provide a compliant plan for facilitating the substance of a six-day regional security-focused workshop (including two travel days) supporting 100 participants from the 11 ASEAN countries and potential additional self-funded participants.

The Food for Progress Program provides for the donation of U.S. agricultural commodities to developing countries and emerging democracies committed to introducing and expanding free enterprise in the agricultural sector. The commodities are generally sold on the local market, and the proceeds are used to support agricultural development activities.   Per the Food Security Act of 1985, (7 U.S.C. § 1736o(d)), the Food for Progress Program has six specific objectives:  Access, on the part of farmers in the country, to private, competitive markets for their products;  Market pricing of eligible commodities to foster adequate private sector incentives to individual farmers to produce food on a regular basis for the country’s domestic needs;  Establishment of market-determined foreign exchange rates;  Timely availability of production inputs (such as seed, fertilizer, or pesticides) to farmers;  Access to technologies appropriate to the level of agricultural development in country; and  Construction of facilities and distribution systems necessary to handle perishable products.    These can be summarized through two high-level strategic objectives: (1) increase agricultural productivity, and (2) expand trade of agricultural products (domestically, regionally, and/or internationally). These objectives work to enhance the competitiveness of American agricultural markets while promoting private sector engagement and encouraging innovation in emerging markets. The Food for Progress Program also represents the America First priorities by investing in strategically selected partner cou...

Through WaterSMART, the Bureau of Reclamation (Reclamation) leverages Federal and non-Federal funding to work cooperatively with States, Tribes, and local entities as they plan and implement actions to increase water supply and hydropower reliability. The WaterSMART Program demonstrably advances Trump administration priorities, such as those identified in Presidential Executive Order 14154 (January 20, 2025): Unleashing American Energy (E.O. 14154) and Secretarial Order 3418, and aligns with other priorities and requirements, such as those identified in Presidential Executive Order 14332 (August 7, 2025): Improving Oversight in Federal Grantmaking (E.O. 14332). The goal of the WaterSMART Applied Science Grants (ASG) Notice of Funding Opportunity (NOFO) is to invite eligible entities to apply for funding to improve access to and use of hydrologic data, develop and improve water management tools, and improve hydrologic modeling and forecasting capabilities.Water managers and reservoir operators rely on hydrologic data, modeling, and water supply forecasts to make decisions to meet future water demands. Water supply forecasts are estimates of current and future water supplies based on measured basin conditions (e.g., such as the quantity of upstream mountain snowpack). Results from these projects will be used by water managers to increase water supply reliability to meet water delivery requirements (e.g., compacts, decrees, etc.), provide flexibility in water operations to be more resilient during droughts, and enhance water supply forecasts to better predict floods and optimi...

Summary: The fiscal year 2026 (FY26) Breast Cancer Research Program (BCRP) Transformative Breast Cancer Consortium Development Award provides successful applicants the time and resources needed to bring investigators and breast cancer consumer advocates together to establish a consortium framework and conduct preliminary research in support of an application to a future, full BCRP Transformative Breast Cancer Consortium Award (pending availability of funds). All applications must address at least one of the FY26 BCRP overarching challenges or provide adequate justification for exception.Distinctive Features:·        This is a development award and is a separate award mechanism from the full FY26 BCRP Transformative Breast Cancer Consortium Award (HT942526BCRPTBCCA). For FY26, investigators may be named as Consortium Director on an application submitted to either (but not both) of these award mechanisms.·        Breast cancer consumer advocates must be active participants in the development and execution of the FY26 BCRP TBCCDA.

This announcement (NOFO) encourages applications for multi-center clinical trials focused on neurological emergencies. Successful applicants will collaborate and conduct the trial within the NIH SIREN Network. The NIH SIREN Clinical Coordinating Center (CCC) will work with the successful applicants to implement the proposed trial efficiently and the SIREN Data Coordinating Center (DCC) will provide statistical and data management support. The NIH SIREN hubs and their affiliated clinical sites will provide on-site implementation of the clinical protocols.The NIH SIREN Network will also be uniquely poised to collaborate with other US and international consortia necessary to conduct larger, definitive trials of promising interventions for neurological emergencies.Multi-center clinical trials in stroke treatment, recovery, or prevention supported by NINDS will be conducted in the NIH StrokeNet, and not within SIREN. Applicants do not need to be part of the existing SIREN infrastructure to apply under this FOA.

The purpose of this document is to advise the public that NOAA/NOS/National Centers for Coastal Ocean Science (NCCOS) Competitive Research Program (NCCOS/CRP) [formerly Center for Sponsored Coastal Ocean Research (CSCOR)/Coastal Ocean Program (COP)] is soliciting proposals for the Prevention, Control and Mitigation of Harmful Algal Bloom (PCMHAB) program. The PCMHAB program seeks to develop and transition technologies and strategies for preventing, controlling, or mitigating harmful algal blooms and their impacts. For this announcement, PCMHAB will prioritize proposals focused on the comprehensive testing of harmful algal bloom control technologies that fit one of the two following focal areas: (1) promising control technologies that are in need of further testing to prove feasibility; and (2) proven control technologies that are still in need of large-scale field testing or that are already approved related control technologies (e.g., freshwater harmful algal blooms, oil spills, etc.) that could be transferable to harmful algal blooms in the marine environment. Funding is contingent upon availability of Federal appropriations. It is anticipated that approximately $2,500,000 may be available to support the first year of three to five projects. Proposals may request up to $500,000 per year for up to 3 years (focal area 1) or up to $1,000,000 per year for up to 5 years. NCCOS/CRP may reject any PCMHAB proposals submitted with an annual budget for any year that is greater than $500,000 for focal area 1 projects or $1,000,000 for focal area 2 projects. --- An informational webi...

A.    Background   The overall goal of this project is to improve water quality conditions in Willow Creek Reservoir for the benefit of the community of Heppner, Oregon, and surrounding area. The reservoir is characterized by several water quality concerns, including dense cyanobacteria (or blue-green algae) blooms, low dissolved oxygen concentrations, and high nutrient concentrations. Cyanobacteria blooms are known to produce toxins, thereby threatening the aquatic ecosystem and potentially exposing humans and animals to risk of death or chronic illness such as neurodegeneration and liver damage. Each summer, Willow Creek Reservoir post’s health advisories warning users of the potential hazards associated with recreational activities on the lake. Furthermore, fish kills, foul odors and other nuisances are common in Willow Creek Reservoir affecting the community’s ambiance, limiting tourism and recreation on the lake.   This analysis draws upon prior research, readily available data, and new research and data to develop and implement an evaluation program for the restoration of Willow Creek Reservoir and its upper basin. Research results will provide public benefit through enhanced water quality in Willow Creek Reservoir producing public recreation opportunities and natural resource benefits. B.    Program Description/Objective   The primary objective is to advance the scientific understanding of reservoir ecology through the following research pillars: 1.   Empirical Data Acquisition and Limnological Analysis: To maintain the integrity of high-resolution, longitudinal data...

The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications for a new Clinical Trial Center (CTC) and up to seven Clinical Centers (CCs) for the HeartShare 2.0 program. The CTC will coordinate precision clinical trial activities focused on heart failure with preserved ejection fraction (HFpEF), including master protocol development, project management, recruitment oversight, performance milestones, and scientific conduct of trials. The CCs will recruit and retain heart failure patients and controls. The CCs will participate in all aspects of conducting a deep phenotyping protocol and longitudinal follow-up of HFpEF patients; obtaining tissue biopsies; and recruiting patients for future clinical trials.Eligible applicants may submit proposals for either the CTC or CC, but must have different PIs. Each application should include CTC or CC as part of their project title.Companion NOFO for RFA-HL-27-009 will support a Data Translation Center (DTC) for overall coordination of the HeartShare program.

This is a Notice of Funding Opportunity (NOFO) for a Single Source that will invites an application from an eligible organization to apply. Please see Section III. Eligibility for additional information. The NHLBI is announcing its intent to issue a single source cooperative agreement to Northwestern University. This NOFO solicits a renewal of the Data Translation Center for an ongoing NHLBI phenomics program, HeartShare, to coordinate the overall project, continue to oversee enrollment of a cohort of patients with heart failure with preserved ejection fraction (HFpEF), curate and analyze prospective deep phenotyping data, and support planning, implementation, and data analysis for clinical trials. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered.Companion NOFO RFA-HL-27-008 will support Clinical Centers for recruitment and follow-up of heart failure patients and a Clinical Trial Center for new clinical trial activities.

This Notice of Funding Opportunity (NOFO) solicits cooperative agreement research applications to support a multidisciplinary program titled "Accelerating Product Excellence in Innovation and for Clinical Adoption" (APEx), that will facilitate advancement of promising strategies and products for tissue engineering and regenerative medicine (TE/RM). APEx will be composed of Resource Centers (RCs) and associated Interdisciplinary Translational Projects (ITPs) in the area of therapeutics (including adult stem cell-based treatments), sensors, and diagnostics. RCs will capitalize on their available clinical, scientific, industrial, regulatory and commercialization expertise, to deliver technical support, research capacity, administrative infrastructure and regulatory and commercialization support to the ITPs and guide them to complete pre-clinical studies toward initiation of clinical trials. During this funding cycle, APEx will complete validation, manufacturing, and preclinical testing of the most promising products, which may include, but are not limited to products for detecting or treating tissue damage caused by congenital defect, traumatic injury, or chronic disease. Products that support early detection of chronic pathologies, monitoring of validated biomarkers of health or disease, as well as approaches to reduce or prevent resulting damage, are especially encouraged. The outcome of APEx will be TE/RM products with their regulatory approvals in place for first-in-human studies, along with associated clinical study protocols, and synthesis and manufacturing protocols rea...

ECA announces an open competition for a cooperative agreement to develop and implement a program that will convene cultural ministers from key countries at an iconic location in the United States for high level discussions on cultural heritage and cultural property protection as part of the State Department’s programming to mark America’s 250th birthday. The implementing partner will work closely with ECA to develop the program’s one-to-two-day exchange agenda, including showcasing innovation and new technologies of the U.S. private sector and other American institutions in the cultural heritage field; strengthening cooperation in combatting art and antiquities trafficking; and using cultural heritage to amplify global narratives on America’s foundational values. The convening will feature U.S. models, standards, and best practices; strengthen relationships with key countries in the cultural heritage field; and produce concrete follow-on steps to advance the program’s agenda. Two to three virtual sessions with working level representatives of the selected cultural ministers will precede the U.S. program, helping gain input into and solidify the agenda. Participants will include 25-40 cultural ministers or equivalents/designees from select countries; representatives from the U.S. government, U.S. companies and other institutions involved in cultural heritage preservation and protection; and U.S. law enforcement focused on combatting art and antiquities trafficking. The program will introduce the foreign participants to U.S. advancements in cultural property protection and pr...

**ACCEPTANCE OF WHITE PAPERS IS SUSPENDED UNTIL FURTHER NOTICE** Defense Production Act Title III Expansion of Domestic Production Capability and Capacity In addition to the below changes, please note, the submission and acceptance of White Papers remains suspended until further notice. Please continue to check SAM.gov for updates.   Amendment 5, dated 1 July 2025, hereby updates the following Funding Opportunity Announcement (FOA) information and sections: Closing Date of the FOA FROM: 12 July 2025 TO: 12 July 2026 Due Date and Time: FROM: Open and Effective date until 12 July 2025. White Papers will be considered if received before 1500 EST on 12 July 2025. TO: Open and Effective date until 12 July 2026. White Papers will be considered if received before 1500 EST on 12 July 2026. Address technical questions to the Technical POC: FROM: Diana M. Carlin, DPA Title III Program AF Executive Agent Program Manager, AFRL./RXM, 2977 Hobson Way, Bldg. 653, Room 308, WPAFB, OH 45433, AFRL.DPA.TtitleIandIII@us.af.mil , 937-904-4591 TO: Jeffrey T. Hubert, Acting DPA Title III Program AF Executive Program Manager, AFRL/RXM, 2977 Hobson Way, Bldg. 653, Room 308, WPAFB, OH 45433, AFRL.DPA.TtitleIandIII@us.af.mil Contracting/Agreements Points of Contact (POC) Agreements Officer Melanie Kiplinger Agreements Specialist Justin (Jay) Hull Schedule: FROM: This FOA will remain open for white paper submissions and Call issuances for a period of seventy-two (72) months. TO: This FOA will remain open for white paper submissions and Call issuances for a period of eighty-four (84) months. Other Requ...

The 811 PRA program promotes the development of innovative state-level strategies to increase access to new and existing affordable supportive housing units for persons with disabilities. The program also supports collaborations between State Housing Agencies and State Health and Human Service/Medicaid Agencies to increase access to supportive services. Many states have already formed partnerships to address this need, and HUD intends to further support these efforts while incentivizing other states to take similar approaches.This program gives states the flexibility to award and administer these funds to address the shortage of affordable and integrated housing for persons with disabilities. Housing agencies may either directly administer the rental assistance contracts for eligible properties or contract with other qualified parties to administer this assistance.

The program will increase the recruitment of qualified candidates from INL Bogota’s priority geographic areas —regions that are critical to U.S. interests due to their high levels of coca production, narcotrafficking, and child recruitment by criminal organizations. By building a more capable and professional police force in these strategically important areas, this scholarship program will help disrupt criminal networks at their source, reducing the flow of illicit drugs, weapons, and human trafficking that threaten the United States. The program will support the recruitment and training of approximately 1,000 CNP students per year: 600 for non-commissioned officer (NCO) roles and 400 for commissioned officer (CO) roles. A stronger Colombian police presence in these regions will advance U.S. national security priorities, safeguard American lives, and promote stability in the Western Hemisphere. The program will provide scholarship support to qualified candidates through a structured financial management system. The implementor will ensure timely monthly electronic funds transfer payments to the bank accounts of scholarship recipients or service providers for required items. Scholarship recipients will receive electronic funds transfers only for approved support expenses. To strengthen internal controls, the implementer will minimize direct cash handling and ensure all disbursement are documented and subject to audit.

Program Description: The purposes of the Personnel Development to Improve Services and Results for Children with Disabilities program are to (1) help address State-identified shortages and needs for personnel preparation in special education and early intervention, including infants, toddlers, children, and youth with disabilities; and (2) ensure that those personnel have the necessary skills and knowledge, derived from practices that have been determined through scientifically based research, to be successful in serving those children. The purpose of the Expanding Career Pathways and Workforce Readiness of Special Education Teachers and Early Intervention Personnel Through Registered Apprenticeships competition is to fund cooperative agreements that support registered apprenticeship1 programs that attract, prepare, and retain special education teachers or early intervention personnel. This priority is particularly relevant for special education and early intervention, where high-quality preparation must be accessible, practice-based, and closely integrated with service delivery systems. Preparing qualified special education teachers and early intervention personnel through registered apprenticeship programs addresses critical workforce shortages, integrating work-based learning, and connecting preparation with local and State labor demands. 1Note: ED encourages applicants to consider the definition of Registered Apprenticeship Program as defined in 5 CFR 362.102 and 29 CFR part 29. Assistance Listing Number: 84.325J. Applicants are required to follow the 2025 Common Instru...

Funding Opportunity Title: Moonshot: Artemis Edition Funding Opportunity Number: PAS-MOROCCO-FY26-02 Deadline for Applications: Monday July 13, 2026 at 23:59 GMT+1  Assistance Listing Number: 19.040 Length of performance period: 12 to 18 months Number of awards anticipated: 1 award Total available funding: $200,000 pending availability of funds  Type of Funding: FY26 Smith Mundt Public Diplomacy Funds  Anticipated project start date: October 2026 Funding Instrument Type: Cooperative agreement.  Project Performance Period: Proposed projects should be completed in 18 months or less. The Department of State will entertain applications for continuation grants funded under these awards beyond the initial budget period on a non-competitive basis subject to availability of funds, satisfactory progress of the program, and a determination that continued funding would be in the best interest of the U.S. Department of State. This notice is subject to availability of funding. A.  Executive Summary: “Moonshot: Artemis Edition” is an 18-month nationwide public diplomacy initiative designed to promote American leadership in space exploration and the Artemis Program by engaging Moroccan youth in science, technology, and entrepreneurship. This initiative will leverage lessons from the Artemis program to help equip participants with practical ability and exposure to real-world applications in the emerging space economy. Commercial diplomacy is a central component of “Moonshot: Artemis Edition”, which will introduce participants to the U.S. space industry and its global leadership. The progra...

The NIST Standards Coordination Office Curricula Development Cooperative Agreement Program (SCOCD CAP) is seeking applications from eligible applicants for activities to develop undergraduate and/or graduate level curricula to incorporate documentary standards, standards development, and standardization of information and content into seminars, modules, courses, and learning resources. The recipients will work with NIST to strengthen education and learn about documentary standards, standards development, and standardization.   

Funding Opportunity Title: Tech Innovation Lab Funding Opportunity Number: PAS-MOROCCO-FY26-03 Deadline for Applications: July 13, 2026 at 23:59 GMT+1 Assistance Listing Number: 19.040 Length of performance period: 12 to 18 months Number of awards anticipated: 1 award Total available funding: $200,000 pending availability of funds  Type of Funding: FY26 Smith Mundt Public Diplomacy Funds  Anticipated project start date: October 2026   Funding Instrument Type: Cooperative agreement. Project Performance Period: Proposed projects should be completed in 18 months or less   The Department of State will entertain applications for continuation grants funded under these awards beyond the initial budget period on a non-competitive basis subject to availability of funds, satisfactory progress of the program, and a determination that continued funding would be in the best interest of the U.S. Department of State.   This notice is subject to availability of funding   A.  Executive Summary: The Tech & Innovation Lab is a national program that equips participants in two to four Moroccan cities with practical skills to use American technology and business practices to solve real-world challenges. The program focuses on applying U.S.-developed tools, including artificial intelligence (AI), to priority sectors such as agriculture, fisheries and the blue economy, logistics, tourism, and services, while introducing participants to U.S. technology platforms and companies operating in these sectors. The Lab aims to strengthen participants’ ability to build solutions that are market-relevant, an...

The purpose of this NOFO is to strengthen public health capacity of 1) Tribal Epidemiology Centers (TECs) and 2) the Tribes, Tribal Organizations, Urban Indian organizations, and Intertribal Consortiums that they support to fulfill the seven functions of TECs as outlined in the Indian Health Care Improvement Act (IHCIA) at 25 U.S.C. 1621m(b). It is the intent of IHS to fund sufficient TECs to serve Tribes and Urban Indian communities in all 12 IHS administrative areas and serving the Urban population as a consolidated Area. Applicant objectives may include activities beyond the required activities but must address all required activities.

This notice of funding opportunity (NOFO) encourages applications for investigator-initiated multi site clinical trials (e.g., efficacy, effectiveness, or pragmatic trials) to study the effects of complementary and integrative health approaches with physical and/or psychological therapeutic inputs (often called mind and body interventions), and/or multicomponent interventions that include physical, psychological, and/or nutritional approaches in NCCIH- designated areas of high research priority. Clinical Coordinating Centers (CCC) should develop and implement the proposed fully powered multi-site clinical trial (Phase III and beyond). The objective of a CCC application is to present the scientific rationale and a comprehensive scientific and operational plan for the clinical trial. CCC applications are expected to describe plans for project management, participant recruitment and retention strategies, performance milestones, scientific conduct, and dissemination of results. CCC applications submitted under this NOFO will utilize a two-phase, milestone-driven cooperative agreement (UG3/UH3) funding mechanism. In addition, an accompanying Data Coordinating Center (DCC) application (U24), submitted under PAR-24-087 proposing a data analysis and data management plan for the clinical project is required. Both a CCC application and a corresponding DCC application need to be submitted simultaneously for consideration by NCCIH. For additional information about the mission, strategic vision, and research priorities of NCCIH, applicants are encouraged to consult the NCCIH website: (h...

This notice of funding opportunity (NOFO), utilizing the U24 grant funding mechanism, encourages applications for a collaborating Data Coordinating Center (DCC) application that accompanies an investigator-initiated multi site clinical trial (Phase III and beyond) application submitted under companion PAR-21-243. The DCC application must be specific to the companion Clinical Coordinating Center (CCC) application. The objective of the DCC application is to propose a comprehensive plan that provides overall project coordination, and administrative, data management, and biostatistical support for the proposed clinical trial. Both a DCC application and a corresponding CCC application need to be submitted simultaneously for consideration by NCCIH. Trials for which this NOFO applies must be relevant to the research mission of NCCIH and considered a high priority by the Center. For additional information about the mission, strategic vision, and research priorities of NCCIH, applicants are encouraged to consult the NCCIH website (http://www.nccih.nih.gov). Applicants are encouraged to contact the appropriate Scientific/Research contact for the area of science for which they are planning to develop an application prior to submitting to this NOFO.

This Notice of Funding Opportunity (NOFO), utilizing the U24 grant funding mechanism, encourages applications for a collaborating Data Coordinating Center (DCC) application that accompanies an investigator-initiated multi-site clinical trial (Phase Ill and beyond) application submitted underTEMP-26943. The DCC application must be specific to the collaborating Clinical Coordinating Center (CCC) application. The objective of the DCC application is to propose a comprehensive plan that provides overall project coordination, and administrative, data management, and biostatistical support for the proposed clinical trial. Both a DCC application and a corresponding CCC application need to be submitted simultaneously for consideration by NCCIH. Trials for which this NOFO applies must be relevant to the research mission of the NCCIH and considered a high priority by the Center. For additional information about the mission, strategic vision, and research priorities of the NCCIH, applicants are encouraged to consult the NCCIH website: (http://www.nccih.nih.gov). Applicants are strongly encouraged to contact the appropriate Scientific/Research contact for the area of science for which they are planning to develop an application prior to submitting to this NOFO.

This Notice of Funding Opportunity (NOFO) encourages cooperative agreement applications for investigator-initiated, multi-site, clinical trials (Phase III and beyond) to study the effects of natural products (i.e. botanicals, probiotics, and products marketed as dietary supplements) in NCCIH designated areas of high research priority. For this NOFO, natural products include promising nutritional regimens that standardize the amount of a specific naturally occurring nutritional compound (e.g., omega-3 fatty acids, anthocyanidins, or polyphenols) and have compelling preliminary evidence. Applicants should describe plans for a Clinical Coordinating Center to develop and implement the proposed multi-site clinical trial. The objective of the Clinical Coordinating Center application is to provide the scientific rationale and a comprehensive scientific and operational plan for the clinical trial. Clinical Coordinating Center applications are expected to describe plans for project management, participant recruitment and retention strategies, performance milestones, scientific conduct, and dissemination of results. Clinical Coordinating Center applications submitted under this NOFO will utilize a two-phase, milestone-driven, cooperative agreement (UG3/UH3) funding mechanism. In addition, an accompanying Data Coordinating Center application, submitted under PAR-24-125, proposing a data analysis and data management plan for the clinical project is required. Both a Clinical Coordinating Center application and a corresponding Data Coordinating Center (DCC) application need to be submitt...