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NIMH is announcing its intent to issue a single source cooperative agreement award to Brigham and Women"s Hospital to support continuation of the AMP® SCZ Data Processing, Analysis, and Coordination Center (DPACC). This allows DPACC to complete the processing and analysis of longitudinal multi-modal biomarker and clinical outcome data collected across 24 months.This is a Notice of Funding Opportunity (NOFO) for a Single Source that will invite application(s) from eligible organization(s) to apply. Please see Section III. Eligibility for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered for funding.

The U.S. Department of State’s Bureau of Counterterrorism (CT) announces a Notice of Funding Opportunity for projects that counter ISIS-K’s online radicalization and recruitment of Central Asian foreign workers, particularly Tajik and Uzbek speakers. ISIS-K uses sophisticated, multilingual online propaganda—including on social media, gaming platforms, and via generative AI—to target vulnerable labor migrants from Central Asia working abroad. This recruitment pipeline creates a persistent risk that seemingly localized radicalization abroad can translate into attacks on U.S. soil or against U.S. persons and assets in key transit hubs. This project is intended to advance early investigative interventions in this recruitment pipeline to close pathways that terrorists can use to move people, money, and operational guidance toward targets in the United States. Activities may include online peer engagement to address isolation among foreign workers; pre-departure and on-arrival consultations; digital literacy training; measures to strengthen trust between local law enforcement and communities to encourage reporting; enhancement of information-sharing platforms; enhanced digital forensics capabilities; and partnerships with experts and non-governmental organizations to identify and disrupt terrorist recruitment online, thereby reducing threats to the U.S. This project should also provide technical assistance to Central Asian law enforcement partners to improve their ability to identify and investigate digital evidence of terrorist recruitment efforts leading to counterterrorism pro...

Direct-fund basic research at universities that complement applied research in nuclear forensics at the DOE National Laboratories to include foundational disciplines of radiochemistry; geochemistry; shock physics; nuclear physics, science and engineering; radiation detector science; nuclear material science engineering; nuclear chemical engineering; modeling, simulation and optimization methods for nuclear applications; and seismology and infrasound methods supporting yield determination. A secondary benefit to this research is the development of a diverse and highly talented cadre of technical professionals, including scientists, engineers, technicians, and operational personnel, who will become the next generation of technical leaders in nuclear missions, such as nuclear forensics, nonproliferation, incident response, intelligence, and energy. These professionals are expected to primarily benefit the DOE National Laboratories as future research staff but will also benefit academia, private industry, and U.S. government agencies, including Energy, State, Defense, Homeland Security, Justice, and the Intelligence Community.

CDC/ATSDR is inviting research proposals to study risk factors for Amyotrophic Lateral Sclerosis (ALS). Studies on military service, contact sports, traumatic brain injury, neuroinflammation, and infections agents and exposures are encouraged. Funding will be for four funding options: Option A - Support research with strong existing evidence such as studies on known environmental or genetic risk factors, research that improves past studies with better data, or investigations linking risk factors to ALS diagnosis and treatment; Option B - Support new and exploratory research on ALS risk factors such as studies on risk factors with little existing evidence or research using innovative methods; Option C - Understand ALS risk in affected populations, such as studies involving military veterans or investigations of ALS risk factors impacting this population; Option D - Analyze biological samples from the Guamanian ALS cluster such as investigation of disease mechanisms and environmental factors, exposure routes, genetic studies and biomarkers and how this could lead to mitigation therapeutics, diagnostics or prevention.

The STRIVE Program’s goal is to strengthen U.S. global leadership by supporting U.S. higher education institutions to equip the next generation of American leaders with the vital knowledge, skills, and relationships needed to advance U.S. commercial and security interests. ECA previously engaged U.S. higher education institutions in similar activities through the IDEAS Program. The STRIVE Program increases the U.S. institutions and students engaging overseas while aligning activities to better support U.S. prosperity and security. The STRIVE Program provides competitively selected subawards and resources to U.S. colleges and universities to establish international partnerships and programming that prepare U.S. undergraduate and graduate students for careers in industries critical to U.S. prosperity and security. The STRIVE Program has three main objectives:·      Increase the number of U.S. higher education institutions developing international partnerships to maintain U.S. global leadership and influence in higher education, counter malign influence of other actors in foreign higher education systems, and align global academic innovation with U.S. priorities. ·      Increase the number of U.S. undergraduate and graduate students studying, interning, apprenticing, and/or researching abroad on programs that prepare them to fulfill domestic labor needs, ensuring a skilled U.S. workforce that can effectively advance U.S. commercial and security interests.·      Increase the strategic locations where U.S. undergraduate and graduate students study, intern, apprentice, and/or res...

The U.S. Department of State's Bureau of Counterterrorism (CT) announces a funding opportunity for a 15-month results-focused cooperative agreement to improve the counterterrorism capabilities of one of the advanced tactical law enforcement units within Kenya’s Administrative Police Services (APS) tasked with securing the border with Somalia. Through the provision of training and necessary equipment, this program will improve operational readiness through three lines of effort: 1) low-light and night-vision ability; 2) using unmanned aircraft systems (UAS) for intelligence, reconnaissance, and surveillance (ISR) purposes; and 3) organic explosive ordnance disposal (EOD) capability. In the Kenyan context, the overall outcome of this program is to further the tactical development of these three skills in order to enhance the security surrounding the Manda Bay Military Base (also known as “Camp Simba”) along the eastern border with Somalia. The military base in Kenya’s Lamu County region is critical to the protection of U.S. military assets and personnel. By strengthening Kenya's ability to secure its border with Somalia, this program directly protects American servicemembers stationed at Manda Bay and prevents terrorists from conducting attacks that threaten American citizens and U.S. interests.

The U.S. Department of State Bureau of Counterterrorism (CT) announces a funding opportunity to establish a Western Hemisphere Counterterrorism Legal and Financial Disruption Program. The program will strengthen recipients’ ability to hold Foreign Terrorist Organizations (FTOs) accountable by improving legal frameworks and disrupting their financial networks. This initiative supports the 2025 National Security Strategy and the Department’s Agency Strategic Plan by deepening regional partnerships to enhance security, counter transnational threats, and protect U.S. interests in the Western Hemisphere. The program will deliver structured legal and financial-disruption training for investigators, prosecutors, and judges across Latin America and the Caribbean. It will focus on investigating, prosecuting, and adjudicating terrorism cases and dismantling FTO networks, including their links to terrorist financing and transnational criminal organizations. The program will also improve information sharing with U.S. counterparts. Applicants must coordinate and deconflict with existing regional training activities, including the International Law Enforcement Academy (ILEA), and should identify other relevant initiatives. The program will emphasize practical skills, multi-agency coordination, and targeted assistance that advance U.S. national security throughout the Western Hemisphere. While the primary focus will be on newly designated FTOs in Latin America and the Caribbean, the program will also support implementation of National Security Presidential Memorandum-2 (NSPM-2) by helping...

The USGS is offering a funding opportunity to a CESU partner for research to characterize tidal creek water chemistry in fresh and salt marshes in Barataria Basin, Louisiana, supporting development of a decision support tool that will assess wetland recovery in response to oil spill damage and subsequent restoration. This activity is intended to support evaluation of restoration actions within the Louisiana Restoration Area; perform data collection, aggregation and analyses; and inform critical information gaps. This work is carried out pursuant to the 33 U.S.C. 2701, 2761Oil Pollution Act of 1990 (OPA) statute and regulations. Consistent with the Consent Decree for the Deepwater Horizon oil spill, the Trustees carry out their obligations according to Final Programmatic Damage Assessment Restoration Plan and Final Programmatic Environmental Impact Statement (PDARP/PEIS), and the Trustee Council Standard Operating Procedures for Implementation of the Natural Resource Restoration for the Deepwater Horizon (DWH) Oil Spill. Trustees, including Department of the Interior, have a responsibility to use allocated funds to restore natural resources and services injured or lost as a result of the DWH oil spill. The Louisiana Trustee Implementation Group (LA TIG) MAM Strategy (LA TIG, 2021) has approved activities to "Contribute to maintaining and restoring ecosystem-scale condition and resilience at coastwide, basin, and subbasin scales" as a high-level objective under the Cross-Restoration Type. Under this high-level objective is the fundamental objective to "maximize the combined b...

The USGS is offering a funding opportunity to a CESU partner for research work intended to evaluate the economic impact of brown treesnake caused power outages in Guam. The work will also evaluate potential economic tradeoffs between different control approaches based on the number and type of outages they prevent.

The U.S. Department of State's Mission Poland announces an open competition for programs inspired by America's 250th anniversary through the Freedom 250 initiative. This initiative will support innovative projects, events, and activities that leverage America’s independence anniversary to highlight U.S. leadership and that celebrate the vibrant cooperation between the United States and Poland in business, defense, energy, science and technology innovation, and culture. Freedom 250 in Poland builds on 250 years of friendship, shared values, and people-to-people ties and invites Polish participants to join America in celebrating the greatest experiment in human history. Freedom 250 looks forward as much as it looks back; it invites partners to engage with the American story in ways that resonate with youth, early-career professionals, community leaders, and opinion makers to forge new partnerships between the United States and Poland that meet today’s needs. Please follow all instructions below.       This opportunity will not support: ·      Projects relating to partisan political activity; ·      Charitable or development activities; including direct social services such as medical, psychological, and/or humanitarian support ·      Construction projects; ·      Projects that support specific religious activities; ·      Fund-raising campaigns; ·      Lobbying for specific legislation or programs ·      Scientific research or surveys; ·      Commercial projects; ·      Projects intended primarily for the growth or institutional development of the organization; ·      Project...

The U.S. Geological Survey Southwest Biological Science Center (SBSC) seeks to provide financial assistance for a research project to help build a program to use new remote sensing platforms to improve understanding of how southwestern U.S. ecosystems work and for management options that can best provide ecosystem services in these challenging ecosystems. This program will focus on remote sensing tools that are best for dryland ecosystems, on biological soil crust communities, and on using remote sensing to inform land management options. The work will also focus on using artificial intelligence (AI), machine learning, and other cutting edge data analysis tools to analyze a range and scale of data that was previously not possible.Nearly 40% of the United States are arid and semiarid ecosystems, thus these drylands are both vast and important. At the same time, remote sensing challenges unique to drylands have made landscape-scale assessments of drylands challenging and thus the power of remote sensing tools has lagged behind their use in more mesic ecosystems. Nevertheless, the utility of improving our ability to use remote sensing for assessing and understanding drylands has myriad uses, including those that directly inform resource managers and decision makers. This would include the creation of innovative remote sensing options for mapping, assessing, and managing for biological soil crusts. Biocrusts are a soil surface community that represent the dominant cover type in many U.S. drylands. It has been proposed to blend emerging remote sensing technology from drones, sat...

Background The FDA Oncology Center of Excellence (OCE) aims to advance the development and regulation of oncology products for patients with cancer. The Pediatric Oncology Program and Rare Cancers Program were established to facilitate and expedite drug development for pediatric and other rare cancers. OCE’s Project Catalyst connects scientific knowledge, creative insight, and medical professionals to foster early-stage product innovation, which is particularly important to address the challenges related to product development for ultra-rare cancers. In collaboration with the National Institutes of Health (NIH) and the OCE, the Foundation for the National Institutes of Health (FNIH) recently launched the design phase of the Ultra-Rare Cancer Treatment Advancement Program (ULTRA), a new public-private partnership dedicated to accelerating the development of innovative ultra-rare cancer treatments.  For the purposes of this NOFO, the FDA OCE refers to cancers with an approximate annual incidence in the U.S. of 300 to 400 people or less as ultra-rare (a more stringent criterion compared to the threshold for a rare disease specified in the Orphan Drug Act based on a U.S. prevalence of

U.S. Embassy Abidjan’s Public Diplomacy Section is seeking proposals to implement a workforce development and skills-building program through its network of American Spaces. This program aims to build a pipeline of skilled, English-capable Ivoirian youth who can support4U.S. trade, investment, and innovation partnerships while expanding economic opportunity and stability in Côte d’Ivoire.The project will target university students, educators, and early-career professionals (ages 17–40) in key cities including Abidjan, Yamoussoukro, Bouaké, and Korhogo. Activities will focus on strengthening employability skills, expanding English proficiency, and developing practical technology skills in areas such as artificial intelligence, coding, and entrepreneurship. The program will also increase engagement with U.S. institutions, experts, and private sector partners.Aligned with U.S. foreign policy priorities, including the Freedom 250 yearlong celebration of the 250th anniversary of the United States, this program will incorporate activities that showcase American leadership, innovation, and commitment to freedom. By equipping participants with market-relevant skills and connecting them to U.S. networks, the program will expand opportunities for American businesses, strengthen commercial ties, and contribute to long-term stability by addressing drivers of irregular migration while inspiring the next generation to partner with the United States.

The U.S. Army Corps of Engineers (USACE), Kansas City District (NWK) intends to enter into a cooperative agreement with a state agency responsible for the administration or implementation of undesirable plants laws of the state, who will provide professional services to assist USACE with the management of undesirable plants on federal lands managed by NWK associated with the Missouri River Bank Stabilization and Navigation, Fish & Wildlife Mitigation Project in St. Charles County, Missouri The cooperative agreement will be awarded pursuant to 7 U.S.C. § 2814 Federal Noxious Weed Act of 1974.  

This NOFO will support research and evaluation of emerging technology implementation and impact for law enforcement purposes. Topics include policies, trainings, operational and staffing issues; communications strategies associated with technology implementation; and impacts of technology implementation and use on public safety and agency budgets. NIJ encourages researchers and practitioners to partner or build on existing researcher-practitioner partnerships to guide the law enforcement community on the best ways to implement technology to solve contemporary problems in policing. Applying for this funding opportunity involves a two-stage process that begins with submission of a concept paper. Based on the merits of the concept paper, NIJ may request that the applicant submit a full proposal. Applicants should not submit a full proposal unless invited. For information on the concept paper format, please see the General Purpose of the Funding section of this NOFO.

The U.S. Army Corps of Engineers (USACE), Kansas City District (NWK) intends to enter into a cooperative agreement with a state agency responsible for the administration or implementation of undesirable plants laws of the state, who will provide professional services to assist USACE with the management of undesirable plants on federal lands managed by NWK associated with the Missouri River Bank Stabilization and Navigation, Fish & Wildlife Mitigation Project in Atchison, Holt, Andrew, Boone, Callaway, and St. Louis County, Missouri The cooperative agreement will be awarded pursuant to 7 U.S.C. § 2814 Federal Noxious Weed Act of 1974.

To provide travel logistics support for law enforcement and criminal justice sector reform assistance programs in Bolivia. This program will enable INL Bolivia to deliver timely technical assistance to key Bolivian agencies working to combat transnational criminal organizations (TCOs) and prevent foreign terrorist organizations (FTOs) from operating in the country.

The United States Department of Agriculture (USDA) Animal and Plant Health Inspection Service (APHIS) Veterinary Services (VS) and Wildlife Services (WS) is announcing the availability of around $12,050,000 in cooperative agreement funding to control and prevent CWD in farmed and wild cervids of which up to $2,000,000 may be awarded through non-competitive cooperative agreements as needed to address CWD outbreaks in farmed cervids. The amount available is based on the fiscal year 2026 (FY26) Congressional appropriations language and directions. Applications must be submitted through ezFedGrants using the funding opportunities highlighted below. Please refer to the Notice of Funding Opportunity (NOFO) attached or the CWD Funding Opportunity website for additional information and hyperlinks to the work plans and the financial plan templates.Wild Cervid: $5,500,000ezFedGrants Opportunity USDA-APHIS-10025-WSNWRC00-26-0001Proposals may include, but are not limited to, the development and implementation of wild cervid CWD surveillance, testing, management, and response activities, including further development and evaluation of techniques and strategies to prevent or control CWD in wild cervids.Wild Cervid – Tribal Nations Only: $500,000ezFedGrants Opportunity USDA-APHIS-10025-WSNWRC00-26-0002Proposals may include, but are not limited to, the development and implementation of wild cervid CWD surveillance, testing, management, and response activities, including further development and evaluation of techniques and strategies to prevent or control CWD in wild cervids on lands owned....

The U.S. Embassy in Kyiv invites proposals from U.S. and Ukrainian not-for-profit organizations for the America House Innovation and Tech Lab, a program designed to strengthen U.S.–Ukraine cooperation in innovation, technology, and creative industries during Ukraine's critical economic recovery period. This Freedom 250 initiative will connect Ukrainian startups, technology leaders, creative entrepreneurs, and emerging innovators with U.S. expertise, companies, and innovation ecosystems to expand opportunities for U.S. partnerships and increase engagement with American organizations, while supporting Ukraine's economic competitiveness and integration with U.S. markets and standards on the occasion of America’s 250th anniversary and beyond.The Lab will provide practical training, real-world U.S. market exposure, and sustained partnerships to help Ukrainian innovators scale to the U.S., partner with American companies, establish U.S.-based operations, and become part of the American innovation ecosystem.Through thematic lectures, workshops, mentorship, networking events, and investor engagement delivered via the Embassy's American Spaces network, participants will develop skills related to U.S. market entry, investment readiness, and strategic communication while building connections with American companies, investors, and accelerators, strengthening long-term U.S.–Ukraine economic and technological cooperation.This program is part of the America House Business Impact Series. All proposals must include programming at two to three American Spaces, including the America Houses i...

The purpose of the program is to support States and Tribes with implementing youth suicide prevention and early intervention strategies for individuals up to age 24.

To carry out a project that protects American communities by enhancing Mexican agencies’ ability to carry conduct undercover operations against transnational criminal organizations and drug cartels threatening U.S. national security. This project will provide recommendations on how the Mexican government could close critical gaps in Mexico’s legal protections and enhance identity management systems for undercover agents, enabling Mexican federal and state law enforcement to safely and reliably conduct undercover operations that support U.S. and Mexican investigations targeting cartels and criminal networks.

The purpose of this program is to provide training and technical assistance, mentoring, and ongoing support for healthcare professionals in general health and behavioral health settings to increase their capacity to identify and treat substance use disorders, especially opioid and alcohol use disorders.

The goal of this NOFO is to gather unique information not collected by other federal programs to gain a better understanding of the resources (e.g., services, supports) and opportunities (e.g., education, employment, housing, social participation) needed to reduce morbidity, mortality, and economic impacts and improve other long-term outcomes for people with autism or Fragile X Syndrome (FXS) across the lifespan. CDC proposes to implement three components in this NOFO.Component A: Survey to Promote Resources and Opportunities for aUtistic Teens and young adults (SPROUT) will utilize cohorts from the Study to Explore Early Development (SEED) Phases 1-3 (collected from 2007-2020), which were case-control studies of autism in children 2-5 years of age. Participants will range from about 10-25 years of age when this NOFO is awarded. SPROUT will be comprised of caregiver and self-report surveys intended to offer unique information on (1) service and support needs and the impact of co-occurring conditions on autistic people and their families and (2) the educational, transitional, social, and/or vocational needs and experiences of autistic adolescents and young adults. Information from these surveys will be used to improve the health and wellbeing of autistic people and their families. These activities are intended to provide data to inform ways to lessen individual, familial, and societal costs associated with autism, reduce morbidity and mortality, and improve health and well-being.Component B: Focus on Advancing Support and Transition with the Fragile X Online Registry With Ac...

The purpose of the Disaster Distress Helpline is to provide immediate, confidential, and accessible emotional support services to individuals and communities across the United States who are experiencing psychological distress related to natural or human-caused disasters.

This Notice of Funding Opportunity (NOFO) seeks applications to optimize instrumentation and device technologies for recording and modulation of neural cells and circuits, to address major challenges and to enable transformative understanding of dynamic signaling in the central nervous system. It is expected that the proposed technologies and approaches have previously demonstrated their transformative potential through initial proof-of-concept testing, and are ready for accelerated refinement through iterative engineering and end-user feedback, appropriate for a path towards sustainable dissemination and user-friendly incorporation into routine neuroscience research. Applications may propose development of instrumentation hardware and/or devices and associated software. Approaches may utilize any modality such as optical, electrical, magnetic, or acoustic recording/manipulation, to target neuronal electrical signals or other forms of neural activity, including intracellular signaling and engagement of non-neuronal cells in circuit function. This NOFO is a re-issue of RFA-NS-21-027, but unlike the previous NOFO the focus is narrowed to technologies associated with recording/manipulation instrumentation and devices, and excludes projects primarily focused on development of molecular reagents. Potential applicants primarily optimizing molecular constructs should consider RFA-MH-22-245 (or its reissue), BRAIN Initiative: Engineering and optimization of molecular technologies for functional dissection of neural circuits (UM1 Clinical Trial Not Allowed). For projects at an earli...