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The Basic Instrumentation Grant (BIG) Program encourages applications from groups of NIH-supported investigators to purchase a single piece of new, costly, specialized, commercially available instrument or an integrated instrumentation system.The BIG Program is limited to institutions that have not received S10 instrumentation funding of $500,001 or greater in any of the preceding 3 Federal fiscal years (FY). Use the following to determine applicable funding periods:for submission in CY 2026, consider S10 funding in FYs 2023-2025;for submission in CY 2027, consider S10 funding in FYs 2024-2026;for submission in CY 2028, consider S10 funding in FYs 2025-2027.The minimum award is $25,000. There is no maximum price limit for the instrument; however, the maximum award is $350,000. Instruments supported include, but are not limited to, basic cell sorters, confocal microscopes, ultramicrotomes, gel imagers, or computer systems.

The Shared Instrument Grant (SIG) Program encourages applications from groups of NIH-supported investigators to purchase or upgrade a single item of high-priced, specialized, commercially available instruments or integrated instrumentation system. The minimum award is $50,000. There is no maximum price limit for the instrument; however, the maximum award is $750,000. Instruments supported include, but are not limited to: light microscopes, biomedical imagers, mass spectrometers, nuclear magnetic resonance spectrometers, flow cytometers, DNA and protein sequencers, biosensors, and X-ray diffractometers.

The High-End Instrumentation (HEI) Grant Program encourages applications from groups of NIH-supported investigators to purchase or upgrade a single item of high-end, specialized, commercially available instruments or integrated systems. The minimum award is $750,001. There is no maximum price limit for the instrument; however, the maximum award is $2,000,000. Instruments supported include, but are not limited to, nuclear magnetic resonance spectrometers, X-ray diffractometers, mass spectrometers, high throughput robotic screening systems, DNA and protein sequencers, biosensors, electron and light microscopes, flow cytometers, and biomedical imagers.

The purpose of this notice of funding opportunity (NOFO) is to solicit applications for pilot projects to identify new druggable targets for pain within the understudied druggable proteome. Awards will support generation of preliminary data and/or tools around eligible understudied protein(s) listed in this NOFO. This NOFO is intended to jumpstart research on understudied proteins within the context of pain and pain management and provide applicants with sufficient funding to perform basic biochemical and/or biological work to further the characterization of understudied proteins to identify new druggable targets for pain. This NOFO is part of the NIH Helping to End Addiction Long Term (HEAL) initiative to accelerate the development of novel medications to treat all aspects of the opioid addiction cycle, including progression to chronic use, withdrawal symptoms, craving, relapse, and overdose.

The purpose of this Notice of Funding Opportunity (NOFO) is to stimulate HIV/AIDS research within the scientific mission areas of the National Institute on Deafness and Other Communications Disorders (NIDCD). Applications should address high priority HIV/AIDS research outlined by the NIH Office of AIDS Research (OAR) (https://www.oar.nih.gov/hiv-policy-and-research/research-priorities) in the areas of hearing, balance, taste, smell, voice, speech, and language.For applications proposing a clinical trial, only low risk clinical trials will be supported.

TechAccess: AI‑Ready America is a national-scale initiative to accelerate Artificial Intelligence (AI) readiness and adoption across the U.S. by strengthening coordination, leveraging partnerships and resources, filling gaps, and scaling what works—so local and state priorities can lead in shaping an AI-driven economy that benefits all Americans. Unlike initiatives centered around K–16 education, AI‑Ready America additionally reaches businesses, public-serving organizations, and individuals, among others, expanding access to AI knowledge, tools, and resources. The program also emphasizes practical implementation through hands‑on assistance and workforce upskilling, including experiential learning such as internships, project‑based work, and apprenticeships, to ensure stakeholders can effectively apply and innovate with AI. The program supports: (1) State/Territory Coordination Hubs (Coordination Hubs) – one inevery state, the District of Columbia (DC), or territory inthe United States – connecting partners, strengthening planning and deployment, and rapidly scaling approaches; (2) A National Coordination Lead (National Lead) – facilitating collaboration and knowledge sharing among Coordination Hubs, coordinating priority economic sectors, and informing national AI strategies; and (3) AI-Ready Catalyst Award Competitions – a series of topic-driven competitions issued over the course of the program to pilot and scale innovative approaches that address critical national AI readiness needs. This funding opportunity focuses on Coordination Hubs. The National Lead will be funded....

The purpose of the Rehabilitation Engineering Research Centers (RERC) program is to improve the effectiveness of services authorized under the Rehabilitation Act by conducting advanced engineering research on and development of innovative technologies that are designed to solve particular rehabilitation problems or to remove environmental barriers. The purpose of this RERC is to conduct research on, develop, and evaluate Artificial Intelligence (AI)-driven assistive and rehabilitation technologies that enhance independence, participation, and quality of life for people with disabilities. Many existing assistive and rehabilitation technologies lack adaptability, personalization, and seamless integration into daily life. AI and machine learning (ML) offer trans-formative potential to address these gaps by enabling smarter, more responsive, and individualized assistive and rehabilitation technologies. AI-driven innovations in assistive and rehabilitation technology can shift them from static tools to dynamic, intelligent systems that continuously learn and adapt in real time to individual preferences, needs, and changing abilities. This grant will have a 60-month project period, with five 12-month budget periods.

The Justice for Families program supports activities to improve the response of the civil and criminal justice system to families with a history of domestic/dating violence, sexual assault, and stalking, or in cases involving child sexual abuse. Activities should improve the capacity of courts and communities to respond to families through court-based and court-related programs; supervised visitation and safe exchange of children and youth by and between parents; training for people who work with families in the court system; and civil legal assistance and advocacy services to victims and nonoffending parents. Eligible applicants are Tribal, state, and local governments, courts, nonprofit organizations, legal services providers, and victim service providers.

The purpose of the Culvert AOP Competitive Grant Program is to provide funding to eligible entities for the replacement, removal, and repair of culverts or weirs that meaningfully improve or restore fish passage for anadromous fish. Anadromous fish are born in freshwater and spend most of their lives in saltwater, returning to freshwater to spawn. Salmon are a well-known example of anadromous fish.

The purpose of the BIT3 Program is to fund the replacement or rehabilitation of county-owned bridges that are classified as Type 3 bridges[1] by the U.S. Department of Interior Bureau of Reclamation (USBR) and cross a water conveyance structure owned by USBR. Eligible applicants under the BIT3 Competitive Grant Program are counties which own a Type 3 bridge crossing a water conveyance structure owned by USBR. Projects eligible for funding are projects for the replacement or rehabilitation of bridges that: (A) are owned by a county; (B) are classified as a Type 3 bridge by USBR; (C) are eligible under the Federal Lands Access Program (FLAP) (23 United States Code (U.S.C.) § 204); and (D) cross a water conveyance structure owned by USBR. The BIT3 Competitive Grant Program does not require a minimum cost share. The Federal share for BIT3 Competitive Grant Program funds shall be 100 percent of funds requested for eligible project scope. [1] Type 3 bridge means any non-USBR-owned bridge over 20 feet in length, or bridge-like structure between 6 and 20 feet in length, that crosses a USBR dam, associated facility, power facility, or land interest (Reclamation Manual Directives and Standards FAC 07-01, as updated on June 9, 2023). An associated facility means all remaining Reclamation facilities other than high- and significant-hazard potential dams. Types of associated facilities include: carriage, distribution, and drainage systems [canals]; pumping and pump-generating plants; tunnels; penstocks, siphons, and pipelines; diversion and storage dams (low-hazard potential) and regula...

The Secretary of the Interior ("Secretary"), through the Division of Energy and Mineral Development (DEMD), Office of Trust Services, Bureau of Indian Affairs (BIA), is soliciting grant proposals from Federally recognized Tribal entities for the Tribal Energy Development Capacity (TEDC) grant. The TEDC grant seeks to build Tribal management, organizational and technical capacity needed to maximize the economic impact of energy resource development on Indian land. Grants may fund development of organizational and business structures for energy development, as well as legal and regulatory infrastructure. Certified Local Governments are encouraged to prioritize projects in support of the celebration of America's 250th birthday (America250). This may include, but is not limited to, preservation 2 planning, interpretation, public engagement, and rehabilitation projects that recognize and honor the nation's founding, history, and cultural heritage.New TERA Pathways Topic Area - As part of this solicitation, applicants may elect to pursue activities aligned with the TERA Pathways Initiative, a strategic capacity building effort focused on supporting Tribal progress toward energy self-determination under the Tribal Energy Resource Agreement (TERA) framework. Applications should specify if they are applying for this topic area.

This NOFO will award up to $165 million in Fiscal Years (FY) 2024 through 2026 funding. FHWA may also award any remaining funds for this program from previous fiscal years under this opportunity. The actual amount available to be awarded under this NOFO will be subject to the availability of funds, including reductions from the authorized funding amounts due to the imposition of the obligation limitation for the Federal-aid highway program per the provisions of the annual appropriations acts. Per statute, 50 percent of NSFLTP funds per fiscal year must be used for projects on Tribal transportation facilities and 50 percent used for projects on Federal lands transportation facilities and Federal lands access transportation facilities (Fixing America’s Surface Transportation (FAST) Act § 1123(h)(1), as amended). Of the latter category, FHWA must award funding to at least one eligible project per fiscal year submitted by the U.S. National Park Service (NPS) for a unit of the National Park System with at least three million annual visitors (FAST Act § 1123(h)(2), as amended). There is no minimum or maximum award amount for NSFLTP Program awards.

This is a notice of funding opportunity (NOFO) for the FY26 Technology and Equipment Program (TEP). This noncompetitive, invitational, funding opportunity provides funding to state, territorial, local, Tribal, and other entities designated under the heading “Community Oriented Policing Services, Technology and Equipment Community Projects / COPS Law Enforcement Technology and Equipment” in the Congressional Joint Explanatory Statement – Division C, which is incorporated by reference into Public Law 119-74, to develop and acquire effective law enforcement equipment, technologies and interoperable communications that assist in responding to and preventing crime and expand the implementation of community policing. Equipment funded under this program should meet any applicable requirements of the National Institute of Standards and Technology's Office of Law Enforcement Standards.

The CFPCGP projects are to be designed to require a one-time contribution of Federal assistance to become self-reliant and meet short- and long-term goals. Applicants are required to address at least one short-term and one long-term CFPCGP goals that best fit the plan or project being proposed to ensure a comprehensive and enduring approach to resolving food and nutrition security and hunger.

The purpose of this program is to support organizations in mobilizing and connecting community resources to increase access to long-term recovery support for people with substance use disorders (SUD) and co-occurring substance use and mental disorders (COD). IMPORTANT NOTE: SAMHSA will accept and review only the first 70 complete, successfully submitted, and high-quality applications received via eRA. Once this threshold is met, the submission portal will close, and no further applications will be considered.

The purpose of the Infant and Early Childhood Mental Health program is to develop or enhance evidence-based programs that promote social-emotional development and address mental health needs among infants and young children.

The purpose of this program is to increase student access to evidence-based support services and mental health care by developing innovative initiatives, activities, and programs to link local school systems with local trauma support and mental health services. Note: At least one award will be made to a tribe or tribal organizations pending adequate application volume.

Eligibility is statutorily limited to emergency medical services agencies operated by local or Tribal government (including fire-based and non-fire based) or an emergency medical services agency that is described in section 501(c) of title 26 and exempt from tax under section 501(a) of title 26. See Eligibility for complete eligibility information.

The purpose of this program is to enhance comprehensive treatment and recovery services for children (ages 11 and under), adolescents (ages 12-17) and young adults (ages 18-25) with substance use disorders and/or co-occurring substance use and mental disorders and their families/primary caregivers.

The purpose of this program is to expand substance use disorder (SUD) treatment and recovery support services in existing drug courts. Grant recipients will be required to implement a coordinated, multisystem approach that combines the legal authority of treatment drug courts with evidence-based SUD treatment services.IMPORTANT NOTE: SAMHSA will accept and review only the first 50 complete, successfully submitted, and high-quality applications received via eRA. Once this threshold is met, the submission portal will close, and no further applications will be considered.

The purpose of this program is for the prevention of suicide, suicide attempts, and deaths by suicide among American Indian/Alaska Native youth and young adults through age 24 in Tribal communities.

The purpose of this program is to provide comprehensive services for pregnant and postpartum women with substance use disorders across the continuum of residential settings that support treatment and sustain recovery.

The purpose of the TOR program is to assist in addressing the overdose crisis in Tribal communities by increasing access to FDA-approved medications for the treatment of opioid use disorder (MOUD), and supporting the continuum of prevention, treatment, and recovery support services for opioid use disorder (OUD) and co-occurring substance use disorders, and stimulant misuse and use disorders, including those involving cocaine and methamphetamine.

The purpose of this program is to improve local awareness among youth and young adults of the risks associated with fentanyl and provide youth and young adults with opioid use disorder and other substance use disorder prevention, treatment and recovery support services.

The GusNIP-PPR, Assistance Listing 10.331, presents the opportunity to bring together stakeholders from distinct parts of the food and healthcare systems and to foster understanding of how prescribing fresh (ONLY) fruits and vegetables might improve the nutrition and health status of participating households. The primary goals of the GusNIP-PPR are to demonstrate and evaluate the impact of projects on:1.     The improvement of dietary health through increased consumption of fruits and vegetables; 2.     The reduction of individual and household food insecurity; and 3.     The reduction in healthcare use and associated costs.