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Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R61/R33 Clinical Trial Required). As part of NIMH's clinical trials pipeline, this NOFO encourages pilot research developing and testing novel psychosocial interventions and/or targets. Consistent with NIMH's emphasis on the experimental therapeutics approach to intervention development, it intends to speed the translation of emergent research in basic, behavioral, cognitive, affect, and neuropsychological science into preventative or therapeutic interventions. This RFA will provide up to two years of support for evaluation of target engagement and establishment of intervention parameters, and up to three years of support to replicate target engagement from prior studies and to test the association between target engagement and change in clinical outcome(s).

NIMH requires an experimental therapeutics approach for the development and testing of therapeutic interventions, in which studies both evaluate the clinical effect of an intervention and generate information about the mechanisms underlying a disorder or an intervention response. As part of NIMHs Clinical Trial Pipeline, this NOFO encourages early stage testing of pharmacologic interventions with novel mechanisms of actions or device-based interventions. More specifically, this NOFO is intended to support early stage testing of pharmacologic or device-based interventions using a protocol design where the presumed mechanism of action of the intervention is adequately tested, to provide meaningful information where target modulation yields a dose-dependent neurophysiological/clinical/behavioral effect.

The goal of this funding opportunity announcement (FOA) is to fund meritorious vision-related research projects that involve secondary data analyses using existing database resources. The development of statistical methodology necessary for improving methods to analyze vision health data using existing vision data may also be proposed.

This funding opportunity announcement (FOA) encourages research grant applications to develop in vitro and/or ex vivo assays and conduct iterative screening efforts to identify and characterize potential therapeutic agents for neurological or neuromuscular disorders. This FOA is part of a suite of Innovation Grants to Nurture Initial Translational Efforts (IGNITE) to advance projects to the point where they can meet the entry criteria for the Blueprint Neurotherapeutics Network (BPN) or other translational programs.

This funding opportunity announcement (FOA) encourages the development and validation of animal models and human/animal tissue ex vivo systems that recapitulate the phenotypic and physiologic characteristics of a defined neurological or neuromuscular disorder. The goal of this FOA is to promote a significant improvement in the translational relevance of animal models or ex vivo systems that will be utilized to facilitate future development of neurotherapeutics. Ideally, models proposed for this FOA would have the potential to provide feasible and meaningful assessments of efficacy following therapeutic intervention that would be applicable in both preclinical and clinical settings. This FOA is part of a suite of Innovation Grants to Nurture Initial Translational Efforts (IGNITE) Program focused on enabling the exploratory and early stages of drug discovery.

Reissue PAR-21-122. This NOFO provides funding to conduct pharmacodynamic, pharmacokinetic, and in vivo efficacy studies to demonstrate that proposed therapeutic agent(s) have sufficient biological activity to warrant further development to treat neurological or neuromuscular disorders that fall under the NINDS mission. Therapeutic agents include small molecules, biologics or biotechnology-derived products. This FOA is part of a suite of Innovation Grants to Nurture Initial Translational Efforts (IGNITE) to advance projects to the point where they can meet the entry criteria for the Blueprint Neurotherapeutics Network or other translational programs.

The purpose of this FOA is to facilitate well planned clinical trials across the cancer prevention and control spectrum aimed at improving prevention/ interception, cancer-related health behaviors, screening, early detection, healthcare delivery, management of treatment-related symptoms, supportive care, and the long-term outcomes of cancer survivors. Although the scientific literature or preliminary data may provide the rationale for conducting a clinical trial, investigators often lack critical information about the study population, accrual challenges, intervention, outcome/ endpoints, data/statistical challenges or operational risks necessary to finalize the trial protocol completely. These information gaps can result in multiple protocol changes before and after trial start-up, leading to the need for additional time and expenses that may prevent study completion. Further, the suitability and feasibility of new trial designs, which minimize infrastructure and reduce costs may need to be tested in the context of a particular intervention, at-risk group, symptom or venue. Preparatory studies may fill information gaps and address unknowns, improving trial design and knowledge of trial feasibility and thus saving NCI time and money.

Expected Outcome:the action is expected to mature and demonstrate (TRL 6-8) innovative technologies in one of the technology areas set out within the scope of the topic:developing and advancing the technology readiness of innovative individual components and/or integrated systems that perform the key functions of fusion power plants (FPPs), in line with the technology area targeted;testing the innovative components and/or systems developed in close-to-real-life conditions, demonstrating the ability to deliver fusion-grade components and/or systems;providing a credible business case, clarifying the potential and perspectives for the commercialisation of the components and/or systems developed, and showing the benefits for the competitiveness and growth of EU companies from the fusion field. Scope:actions funded under this topic are expected to address one of the following technology areas...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:Police Authorities in Europe benefit from a rapid deployment of targeted detection and investigation tools and related training materials, specifically tailored to counter current, foreseeable and emerging online harms at the outset of each development cycle;Police Authorities in Europe are provided with a flexible framework for adaptation via creation of a modular toolset that allows for the incorporation of new functionalities and updates based on the latest trends and threats in online harms;Enhanced European stakeholder collaboration through facilitation of partnerships among researchers, policymakers, and Police Authorities in Europe to ensure that tools are not only effective but also user-friendly, legally and ethically sound. Scope:As the digital landscape continues to evolve, so...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:New tools, skills and methodologies for Police Authorities in Europe to deal efficiently with diverse communities as well as with diversity among police personnel are identified, developed and disseminated throughout Europe, leading to, among others, an increased trust to Police Authorities in general;Modern and effective training curricula for Police Authorities in Europe are developed on community policing in diverse societies, including post-conflict zones, and addressing the needs of individuals from various social, ethnic and religious backgrounds, as well as marginalized groups such as migrants, LGBTIQ people, persons with disabilities, or returnees from war. Scope:This topic addresses challenges of community policing in increasingly diverse and sometimes also fragile societies, in...

Expected Outcome:Project results are expected to contribute to some or all of the following expected outcomes:Development, testing and integration of issuance, validation and sharing capabilities for possible future types (beyond Type 1) of Digital Travel Credentials (DTC);Integration of innovative, on-the-move, biometrics and remote biometric acquisition modalities to support the use of DTCs;Improved secure connectivity and interoperability for future DTCs;Improved capability of issuance of emergency travel documents and/or emergency DTCs. Scope:Issuance, verification and management of digital travel credentials (DTCs) is relevant for border management, immigration and visa management. Furthermore, it could also be relevant to combat illicit activities such as terrorism, crime or frauds. This topic aims at supporting research and innovation that explore, develop and test enhanced capabi...

Expected Outcome:Project results are expected to contribute to some or all of the following expected outcomes:Development of decision support systems for disaster crises, utilizing near real-time data from the ground to enhance situational awareness and response;Creation of systems designed to bolster civil preparedness, that enhance operational efficiency and response times, ensuring timely and effective management of various disaster scenarios including from early warning to early actionIntegration of advanced data analysis and decision-making tools to support authorities and first responders in disaster situations. Scope:This topic focuses on enhancing existing decision support systems for disaster crises by integrating emerging technologies to improve civil preparedness and crisis management. The objective is to advance the capabilities of existing systems, making them more reliable,...

Expected Outcome:Project results are expected to contribute to some or all of the following expected outcomes:Developed of advanced protective gear specifically designed for optimal performance in Chemical or Biological or Radiological, and Nuclear or Explosives (CBRN-E) environments;Created innovative smart protective equipment for disaster responders, incorporating advanced technologies to enhance safety and operational efficiency;Improvement of protective solutions to ensure the safety and effectiveness of disaster responders operating in hazardous and high-risk environments. Scope:This topic aims to advance the development of protective gear specifically designed for optimal performance in specificities of the Chemical, Biological, Radiological, Nuclear, and Explosives (CBRN-E) environments, along with the creation of a new generation of smart protective equipment for disaster respon...

Expected Outcome:Project results are expected to contribute to some or all of the following expected outcomes:Development of a mature technological solution addressing EU security policy priorities in the areas addressed by the Cluster 3 work programme and in particular the destination of fighting crime and terrorism, disaster resilient societies, border management and resilient infrastructure;Facilitate increased and sustained collaboration between small and medium-sized enterprises (SMEs), public research partners, and academia, leading to improved knowledge transfer within the European innovative SME ecosystem;Mitigate difficulties in access to finance and new international markets, thereby enhancing the growth and expansion of European innovative SMEs. Scope:Europe’s 25 million small and medium enterprises (SMEs) are the backbone of the EU economy. SMEs can bring innovation to societ...

Expected Outcome:Project results are expected to contribute to some or all of the following outcomes:Critical infrastructure operators and authorities have improved physical risks and hazards assessment capabilities;Perimeter security, access control, surveillance systems, remote sensors and other systems used by or relevant to critical infrastructure operators are capable of coping with threats from misuse of new and emerging technologies;Improved operational procedures, including incidents management and training curricula, are developed;Innovative solutions for critical infrastructure resilience are being developed, utilising recent advancements in spatial planning, security-by-design, preparedness-by-design and nature-based solutions using an inclusive approach that address diverse needs. Scope:Physical protection of critical infrastructure should keep up its advancement to match ris...

Expected Outcome:Project results are expected to contribute to some or all of the following expected outcomes:Increased security of air, maritime, land, or postal transport, cargo and supply chain;Address accidental or intentional explosions, fires, noxious chemicals, material degradation, or autonomous threats in cargo;Enhanced capabilities to detect, characterise, track and trace, and seize dangerous, regulated, illicit devices, goods, or material;Increased mobility of the customs authorities’ resources and equipment and improved agility for a faster and more coordinated response;Interoperability of customs control equipment and interconnectivity with other systems, including integration of logistical operations, and/or increased inter-agency and cross border collaboration. Scope:Today’s global economy and high-volume trade flows require much and fast transport to deliver products worl...

Expected Outcome:Project results are expected to contribute to some or all of the following expected outcomes:Enhanced ability of Police Authorities in Europe and other relevant security practitioners to identify and prevent emergent challenges in the terrorism-related issue under consideration;Harmonised and modern tools as well as procedures are available for Police Authorities in Europe and other relevant security practitioners to counter the terrorism-related problem under consideration, in full compliance with applicable legislation on protection of personal data and protection of fundamental rights;Improved cooperation between Police Authorities in Europe and other relevant security practitioners, as well as with international actors, in tackling the problem in question;Training curricula are available for Police Authorities in Europe and other relevant security practitioners for a...

Expected Outcome:Project results are expected to contribute to some or all of the following expected outcomes:Improved, modern, uniform and validated tools, skills or methodologies as well as innovative training curricula are available for security practitioners (Police Authorities in Europe, Non-Governmental Organisations, Civil Society Organisations) to prevent, detect and deter criminal or terrorist offences under consideration, taking into account all applicable legislation and fundamental rights;Enhanced understanding of the cultural and societal aspects of crime or terrorism/radicalisation offences under consideration as well as on the key challenges related to combating them;Evidence-based support is available to policymakers on shaping and tuning of regulation related to crime or terrorism/radicalisation offences under consideration;Enhanced perception by citizens that Europe is...

Expected Outcome:Project results are expected to contribute to some or all of the following outcomes:Critical infrastructure operators and authorities have improved awareness of Open-Source Intelligence (OSINT) and their potential impact on security of their operations;Toolbox for OSINT mapping, including enhanced analysis and risk flagging is developed and available to relevant stakeholders;Critical infrastructure operators and authorities have improved incident response, emergency plans and business continuity models;Removal of potentially harmful OSINT from the public domain in order to counter/prevent preparations and attempted attacks against critical entities, including the lone wolf and hybrid scenarios;Awareness campaigns and training curricula for critical entities’ employees are developed. Scope:The malicious use of Open-Source Intelligence (OSINT) is a known concern and techni...

Expected Outcome:Project results are expected to contribute to some or all of the following expected outcomes:Establish a consolidated group of potential buyers with shared needs and requirements, committed to carrying out a pre-commercial procurement (PCP) action for future joint procurement of innovative solutions;Evidence for Future PCP Action: Provide clear evidence justifying the necessity of a PCP action to complete the maturation cycle of certain technologies and compare different alternatives;Increased capacity of EU public procurers to align requirements with industry and future products and to attract innovation and innovators from security and other sectors through common validation strategies, rapid innovation, experimentation and pre-commercial procurement. Scope:End-users and public procurers from several countries are invited to submit proposals for a preparatory action th...

Expected Outcome:Project results are expected to contribute to the following expected outcome:Improved border management solutions that protect and promote fundamental rights of both EU citizens and Third Country Nationals. Scope:Under this Open topic, proposals are welcome to address new, upcoming or unforeseen challenges and/or creative or disruptive solutions that are not covered by the other topics of this Destination in 2026 and 2027.In particular, this topic will fund research projects that explore, develop and test knowledge and technology solutions in the areas of border surveillance, border checks, customs and supply chain security, and civilian maritime and aviation security border management that protect and promote fundamental rights of both EU citizens and Third Country Nationals, and EU values.Adapted to the nature, scope, type and target TRL of proposed projects, proposals...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:Evidence base is improved for effective prevention, treatment and harm reduction of synthetic drugs and stimulants in Europe;Relevant European security practitioners, notably Police Authorities, Civil Society Organisations and Non-Governmental Organisations, are equipped with skills, tools and technology aimed at reducing the violence and offences associated with use and marketing of these substances, as well as at combatting drug trafficking from its origin to destination (i.e., through the entire supply chain);Increased understanding of relevant European security practitioners and policymakers regarding the influence of external drivers of change of societal, technological, legal, economic and ethical nature to the availability and use of different types of synthetic drugs and drug mar...

Expected Outcome:Project results are expected to contribute to some or all of the following expected outcomes:Developed a tailored education programs for younger generations, incorporating digital tools and gamification to enhance disaster awareness and engagement;Strengthened societal resilience by actively involving younger generations, citizens, and local authorities in disaster preparedness and response initiatives;Promoted collaborative research that integrates youth perspectives and community involvement, fostering a more resilient society in the face of disasters and crises;Enhanced resilience and behaviour of children, young people, and other groups in a vulnerable situation before, during, and after climate-related disasters and health emergencies;Training and education tools to engage young people and other populations a vulnerable situation in preparedness and crisis managemen...

Expected Outcome:Project results are expected to contribute to some or all of the following expected outcomes:Utilization of virtual and augmented reality training to simulate large-scale and transboundary disasters, improving disaster management’s readiness and response capabilities;Development of diverse crisis scenarios using VR/AR technology, providing immersive, practical training experiences for emergency personnel, responders and decision makers;Strengthened ability of responders and decision-makers to manage large-scale, cross-border disaster scenarios through advanced, technology-driven training programs;Improved knowledge/experience-sharing from past emergencies to cope with future emergencies, also strengthening trans-national knowledge and data exchange among EU countries as well as from early warning to early action. Scope:The scope of this topic is on enhancing preparedness...

This Notice of Funding Opportunity (NOFO) seeks to stimulate HIV/AIDS research within the mission of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) that align with the HIV/AIDS research priorities outlined by the NIH Office of AIDS Research (OAR). These priorities were most recently described in NOT-OD-20-018 UPDATE: NIH HIV/AIDS Research Priorities and Guidelines for Determining HIV/AIDS Funding.