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Summary: The fiscal year 2026 (FY26) Multiple Sclerosis Research Program (MSRP) Clinical Trial Award (CTA) supports the rapid implementation of clinical trials with the potential to have a significant impact on the treatment or management of multiple sclerosis. All applications must address at least one of the FY26 MSRP CTA focus areas. Clinical trials may evaluate promising new products, pharmacologic agents (drugs or biologics), devices, clinical guidance and/or emerging approaches and technologies.Distinctive Features: The FY26 CTA offers two funding levels. The following are generalized descriptions of the scope of research appropriate for each funding level:• Funding Level 1 (CTA-FL1) supports small-scale, proof-of-principle clinical trials (e.g., pilot, first-in-human, phase 0) to demonstrate feasibility or inform the design of more advanced trials, or other clinical trials that are appropriate for this funding level. Preliminary data relevant to the proposed clinical trial are required.• Funding Level 2 (CTA-FL2) supports larger-scale clinical trials at phase 1 or phase 2 that seek to show preliminary evidence of safety or efficacy (i.e., benefit of clinical or paraclinical outcomes) in relevant patient populations. Clear description and justification should be provided, which could include, but is not limited to, the intervention type, trial duration, sample size, outcome measures, assessment tools and frequency of assessment. Preliminary data relevant to the proposed clinical trial in MS populations are required.For the purposes of this funding opportunity, Regulat...

Summary: The fiscal year 2026 (FY26) Multiple Sclerosis Research Program (MSRP) Exploration – Hypothesis Development Award (EHDA) supports the initial exploration of innovative, high-risk, high-gain, and potentially groundbreaking concepts in the Multiple Sclerosis (MS) research field. The studies supported by this award mechanism are expected to lay the groundwork for future avenues of scientific investigation. All applications must address at least one of the FY26 MSRP EHDA focus areas. The proposed research project should include a well-formulated, testable hypothesis based on strong scientific rationale and study design. The presentation of preliminary and/or published data is not required.Distinctive Features: This funding mechanism includes two options: Established Investigator and New Investigator. The New Investigator option supports applicants early in their faculty appointments.

Summary: The fiscal year 2026 (FY26) Multiple Sclerosis Research Program (MSRP) Early Investigator Research Award (EIRA) supports Multiple Sclerosis-focused research opportunities for individuals in the early stages of their careers, under the guidance of one or more designated Mentors. All applications must address at least one of the FY26 MSRP EIRA focus areas.Distinctive Features: This opportunity allows for early-stage investigators to develop a research project, investigate a problem or question in MS research, and further their intellectual development as an MS researcher of the future. All application components for the EIRA are expected to be written by the Principal Investigator (PI), with appropriate direction from the Mentor(s).

The National Aeronautics and Space Administration (NASA) Headquarters has released the solicitation Early Stage Innovations for In Situ Resource Utilization (ESI26-ISRU), as an appendix to the Research and Technology Mission Directorate (RTMD) umbrella NASA Research Announcement (NRA) titled "Space Technology Research, Development, Demonstration, and Infusion 2026 (SpaceTech REDDI 2026).”. The solicitation is available by opening the NSPIRES homepage at https://nspires.nasaprs.com/, selecting “Open” under "Solicitations," and searching "Early Stage Innovations (ESI26)” under Keywords, or directly via https://solicitation.nasaprs.com/NNH26ZTR001N-26ESI_B7.      Through ESI, Space Technology Research Grants (STRG) Program within RTMD solicits proposals from U.S. institutions of higher education (IHEs) for innovative, early-stage space technology research of high priority to NASA. Proposals are sought on specific space technologies that are currently at low Technology Readiness Levels (TRLs). The solicitation exclusively seeks proposals that are primarily responsive to civil-space needs and use cases and not terrestrial and/or non-civil-space applications.    The solicitation exclusively seeks proposals that are responsive to the following topic: Lunar In Situ Resource Utilization Water Purification.    Only U.S. IHEs are eligible to submit proposals to this Appendix. The Principal Investigator (PI) must be either a tenured faculty member or an untenured faculty member on the tenure track from the proposing IHE. Teaming and collaboration are permitted, subject to the restricti...

The National Aeronautics and Space Administration (NASA) Headquarters has released the solicitation Early Stage Innovations (ESI), as an appendix to the Research and Technology Mission Directorate (RTMD) umbrella NASA Research Announcement (NRA) titled "Space Technology Research, Development, Demonstration, and Infusion 2026 (SpaceTech REDDI 2026).”. The solicitation is available by opening the NSPIRES homepage at https://nspires.nasaprs.com/, selecting “Open” under "Solicitations," and searching "Early Stage Innovations (ESI26)” under Keywords, or directly via https://solicitation.nasaprs.com/NNH26ZTR001N-26ESI_B2.    Through ESI26, Space Technology Research Grants (STRG) Program within RTMD solicits proposals from U.S. institutions of higher education (IHEs) for innovative, early-stage space technology research of high priority to NASA. Proposals are sought on specific space technologies that are currently at low Technology Readiness Levels (TRLs). The solicitation exclusively seeks proposals that are primarily responsive to civil-space needs and use cases and not terrestrial and/or non-civil-space applications.    The solicitation exclusively seeks proposals that are responsive to one of the following eight topics:  Acceleration of Computational Fluid Dynamics of High-Enthalpy Hypersonic Flows Using Advanced Numerics and Machine Learning   Advancements in Autonomous Maintenance and Manufacturing Technologies for the Moon and Mars  Computational Techniques for the Design and Characterization of Oxidation-Resistant Refractory Alloys for Aerospace Applications   Entry-Induc...

The U.S. Department of State, Bureau of Democracy, Human Rights, and Labor (DRL) announces an open competition for organizations interested in submitting applications for a rapid response mechanism to support Track 2.0 style peacebuilding convenings in conflict-affected regions of strategic importance to the United States. This program will provide flexible, timely support for convening civil society actors, activists, journalists, and other key stakeholders who are essential to advancing and sustaining peace processes in priority regions including Armenia, Azerbaijan, Cambodia, Thailand, DRC, Rwanda, and other conflict affected regions of strategic importance.

Freedom of expression online faces threats globally from authoritarian governments employing sophisticated technology to restrict speech, control the flow of information, and chill dissenting voices. These challenges infringe on privacy; access to information; and the exercise of freedoms of expression, peaceful assembly, association, and religion or belief online. The misuse of commercial spyware is increasingly deployed by authoritarian governments and other digital threat actors to suppress dissent and restrict freedom of expression and privacy. Artificial Intelligence (AI) is now facilitating cyberattacks, lowering the barrier of entry for threat actors and improving their efficiency and effectiveness.

The U.S. Department of State, Bureau of Democracy, Human Rights, and Labor (DRL) announces an open competition for organizations interested in submitting applications for a rapid response mechanism to support Track 2.0 style peacebuilding convenings in conflict-affected regions of strategic importance to the United States. This program will provide flexible, timely support for convening civil society actors, activists, journalists, and other key stakeholders who are essential to advancing and sustaining peace processes in priority regions including Armenia, Azerbaijan, Cambodia, Thailand, DRC, Rwanda, and other conflict affected regions of strategic importance.

Freedom of expression online faces threats globally from authoritarian governments employing sophisticated technology to restrict speech, control the flow of information, and chill dissenting voices. These challenges infringe on privacy; access to information; and the exercise of freedoms of expression, peaceful assembly, association, and religion or belief online. The misuse of commercial spyware is increasingly deployed by authoritarian governments and other digital threat actors to suppress dissent and restrict freedom of expression and privacy. Artificial Intelligence (AI) is now facilitating cyberattacks, lowering the barrier of entry for threat actors and improving their efficiency and effectiveness.

The U.S. Department of Agriculture, Foreign Agricultural Service, announces this Notice of Funding Opportunity (NOFO) to support the E (Kika) de la Garza Emerging Markets Program (EMP) by issuing new awards. The purpose of this program is to develop, maintain, or expand markets for exports of United States agricultural commodities and to promote cooperation and exchange of information between agricultural institutions and agribusinesses in the United States and emerging markets. This opportunity is available to U.S. entities to achieve the purposes of this program by: (1) making assessments of food and rural business systems needs; (2) making recommendations on measures necessary to enhance the effectiveness of food and rural business systems, including potential reductions in trade barriers; and (3) identifying and carrying out specific opportunities and projects to enhance the effectiveness of food and rural business systems in emerging markets.

Under the Cooperator Program, USDA/FAS enters into agreements with nonprofit agricultural trade organizations (“Cooperators”) to share the costs of maintaining and developing foreign markets for United States agricultural commodities and products. Financial assistance under the Cooperator Program is made available on a competitive basis, and USDA/FAS endeavors to enter into agreements with eligible Cooperators to cover as broad an array of agricultural commodities as possible. All U.S. agricultural commodities, except tobacco, are eligible for consideration.

Under MAP, USDA/FAS enters into agreements with Participants to share the cost of certain marketing and promotion activities to expand exports of U.S. agricultural commodities. Financial assistance under the MAP is made available on a competitive basis, and USDA/FAS endeavors to enter into agreements with eligible Participants to cover as broad an array of agricultural commodities as possible. All U.S. agricultural commodities, except tobacco, are eligible for consideration.

The QSP is designed to encourage the development and expansion of export markets for U.S. agricultural commodities by assisting U.S. entities in providing commodity samples to potential foreign importers to promote a better understanding and appreciation for the high quality of U.S. agricultural commodities.

The TASC program is designed to assist U.S. organizations by providing funding for projects that seek to remove, resolve, or mitigate existing or potential sanitary, phytosanitary, or technical barriers that prohibit or threaten the export of U.S. specialty crops.

The U.S. Environmental Protection Agency (EPA) is soliciting applications under the authority of the Clean Water Act (CWA) section 104(b)(8) to provide Technical Assistance and Training for Rural, Small and Tribal Municipalities and Wastewater Treatment Systems. The program supports small, rural, and Tribal communities’ efforts to identify water challenges, develop plans, build technical, financial, and managerial capacity, comply with CWA requirements, and access water infrastructure funding.Through this Notice of Funding Opportunity under the Clean Water Act, EPA will achieve greater protection of public health and the environment through an increase in trained water sector personnel, access to funding and financing for wastewater treatment facilities, and Clean Water Act compliance. This action advances the Administration’s priorities, including to Make America Healthy Again, by improving water quality and reducing exposure risks, and enabling responsible economic growth for small, rural, and tribal communities through improved wastewater infrastructure. In partnership with States, Tribes, and local governments and grounded in sound science and the law, EPA will deliver cleaner water, stronger infrastructure, and long-term environmental stewardship for all Americans.The proposed activities support the Agency’s Powering the Great American Comeback Initiative’s Pillar 1: Clean Air, Land, and Water for Every American. Priority Areas identified in this opportunity are:(1) Technical assistance and training for rural, small, and Tribal municipalities for planning, developing a...

The U.S. Department of Agriculture, Foreign Agricultural Service, Fellowship Programs, announces this funding opportunity to support the Norman E. Borlaug International Agricultural Science and Technology Fellowship Program by issuing a new award. This opportunity is available to State cooperative institutions or other colleges and universities in the United States, as defined at 7 U.S.C. § 3103. This program is intended to support applied research, extension, and education collaborations between U.S. researchers and their foreign counterparts from selected emerging market economies.Benefits to the United States: This program makes America more prosperous by strengthening trade and expanding and developing new markets with current and potential trading partners.

The U.S. Department of Agriculture, Foreign Agricultural Service, Fellowship Programs, announces this funding opportunity to support the Cochran Fellowship Program by issuing a new award. This opportunity is available to State cooperative institutions or other colleges and universities in the United States, as defined at 7 U.S.C. § 3103. This program is intended to support applied research, extension, and education collaborations between U.S. researchers and their foreign counterparts from selected emerging market economies.Benefits to the United States:• This program makes America more prosperous by increasing American agricultural exports to new or expanded overseas markets.

The TCEP-CA under assistance listing 10.517, supports informal, community-based extension projects that address agriculture, youths, economic development, healthy lifestyles, natural resources, or other topics important to Tribal communities. This NOFO will begin a new 4-year continuation funding cycle. 

The U.S. Department of State’s Embassy Bujumbura announces an open competition to implement a program to support U.S. policy objectives and promote shared interests. Projects must promote Freedom250 and align with policy goals such as making the United States safer, stronger, and more prosperous. Specifically, the projects should showcase American leadership and excellence in sports-particularly in Basketball, and health, notably by celebrating American sports excellence during the American decade of sports. The target audience should be youth and young professionals aged 15-35 representing emerging voices, as well as opinion leaders to convey information and reach the broader population. The program shall pursue four core goals: advancing U.S. public diplomacy, strengthening people-to-people ties, capitalizing on the Decade of Sport, and promoting physical and mental health. Together, these efforts will position Sports as a catalyst for goodwill, cultural exchange, and community well-being.

The National Earthquake Hazards Reduction Program (NEHRP) is a coordinating program for earthquake monitoring, research, implementation, education, and outreach activities developed and conducted by these four agencies: • Federal Emergency Management Agency• National Institute of Standards and Technology• National Science Foundation, and• U.S. Geological SurveyFEMA awards non-competitive, grants to eligible states and territories with high to very high seismic risks to fund one or more of the following allowable activities. The purpose is to support the establishment of earthquake hazards reduction programming and the implementation of earthquake safety, mitigation, and resilience activities at the state and local level.In accordance with this Individual State Earthquake Assistance (ISEA) NOFO, funds available to eligible states and territories classified as having a high or very high risk of earthquakes. Participation in this funding opportunity is limited to states and territories that can provide a statutory non-federal cost share of 25%. However, the cost share requirement does not apply to territories classified as "Insular Areas," such as the U.S. Virgin Islands, which are still eligible to participate in the program.All activities funded by the ISEA grant program must be consistent with the NEHRP vision, mission, and strategic goals.

The U.S. Geological Survey's (USGS) Fort Collins Science Center is offering a cooperative-agreement funding opportunity to a CESU partner having capability to conduct research and studies related to the long-term demography of bumble bees, with a focus on imperiled species. The research will focus on Bombus affinis (rusty patched bumble bee), the previously-widespread bumble bee species whose populations have declined precipitously over the past two decades. This project will leverage collaborations to incorporate expertise in bumble bee ecology into a large existing project supporting the recovery of endangered and imperiled bumble bees. Current research interests include (1) the establishment and maintenance of site surveys to document long-term trends of rusty patched bumble bee, (2) studies that explore novel technologies for the monitoring of bumble bees, (3) studies that assess the types of sampling effort needed to achieve statistically viable assessments of bumble bee population trends, and (4) efforts to facilitate the compilation of data on bumble bee demography. The outcome of a successful agreement will be research products that help DOI and other land-management partners better understand and implement recovery strategies for imperiled bumble bees. Through this CESU agreement, the federal and state university partners will cooperate fully in development of a research program that will produce final products to be used in support of management decisions pertaining to bumble bees. The cooperation of the USGS and its CESU partner brings a combination of expertise....

This $498,000 non-competitive cooperative agreement is available to the Oklahoma Tribal Engagement Partners (OKTEP). This cooperative agreement is a continuation of work previously initiated by FNA through a needs assessment to understand the topics Food Distribution Program on Indian Reservations (FDPIR) staff were interested in learning about in a nutrition paraprofessional training program.OKTEP will utilize this cooperative agreement to continue offering the FDPIR nutrition paraprofessional training, known as the Community Nutrition Champion Training (CNCT), to FDPIR staff. Additionally, OKTEP will address participant requests and deliver an advanced version of the training, CNCT 2.0, to build on previous knowledge gained through the first CNCT curriculum and provide a more comprehensive nutrition education experience for attendees.

Goals and Objectives• Celebrate American Excellence:o Showcase American innovation, technological leadership, and entrepreneurial spirit, celebrating American dynamism or telling America’s story of excellence.o Highlight U.S. achievements in science, technology, sports, industry, and culture.o Demonstrate the excellence and reliability of American products, services, and standards.o Promote American values of free enterprise, individual liberty, and merit-based achievement.• Make America Safero Combat Illegal Immigration: Support programs that address root causes of migration by promoting economic opportunity and security in Bolivia, reducing pressure on U.S. borders.o Counter Transnational Crime: Build Bolivian capacity to combat narcotics trafficking, particularly synthetic drugs and fentanyl precursors, and dismantle criminal networks that threaten U.S. communities.o Enhance Border Security Cooperation: Strengthen information-sharing and law enforcement collaboration between U.S. and Bolivian authorities.o Counter Foreign Anti-American Propaganda and Influence Operations: Expose and counter efforts by adversarial nations to establish strategic footholds that could threaten U.S. interests in the Western Hemisphere.• Make America Strongero Promote Transparency and Anti-Corruption: Support investigative journalism, government accountability mechanisms, and civil society oversight that expose corruption and strengthen democratic institutions aligned with U.S. interests.o Strengthen Rule of Law: Build capacity in judicial and law enforcement institutions to combat crime and u...

U.S. Mission Iraq through the U.S. Department of State is pleased to announce that funding is available through its Public Diplomacy Grants Program. This is an Annual Program Statement outlining our funding priorities and the procedures for submitting requests for funding.

The U.S. Department of State's Embassy in the Philippines announces an opportunity to implement a professional exchange program bringing approximately twelve high-merit educators from the Philippines, Japan, South Korea, Taiwan, and Brunei to the United States for direct, immersive exposure to American approaches to AI and educational technology integration in English language instruction. Participants are selected based on professional merit and institutional influence, and include university professors, language instructors, academic administrators, curriculum planners, teacher trainers, and ministry officials with the authority to shape national policy and procurement decisions in their home countries.Over a two-week exchange spanning at least two U.S. cities, participants engage in a structured program combining academic sessions, community site visits, and direct engagement with American industry and civil society. Site visits include U.S. companies working at the frontier of AI and educational technology, as well as organizations focused on responsible AI governance and human-centered technology frameworks, equipping participants to evaluate AI tools against both commercial and ethical standards. Structured roundtables and professional networking sessions connect participants with American educators and EdTech industry leaders throughout the exchange, culminating in attendance at SXSW EDU in March 2027 in Austin, Texas.Each participant produces a concrete action plan for implementing American-aligned AI and EdTech approaches within their home institution. A sustained....