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In response to a longstanding congressional mandate (P.L. 98-619, Departments of Labor, Health and Human Services, and Education and Related Agencies Appropriation Act, 1985), NIMHD invites applications from eligible institutions to establish a national coordinating center (CC) for the Research Centers in Minority Institutions (RCMIs) initiative. The RCMI CC will coordinate activities across funded RCMI U54 Centers, prospectively evaluate the overall RCMI program, and serve as a national resource to help these centers achieve their primary goals. The RCMI CC will be responsive to requests generated by RCMI site key personnel, NIMHD, NIH, the scientific community, and the general public.

The Supply Chain Acceleration and Logistics Enablement (SCALE) Program supports organizations that help small businesses overcome operational, technical, workforce, and market access barriers that limit their ability to participate and grow as suppliers within strategically important industries. Through technical assistance, industry engagement, and other implementation focused activities, SCALE helps small businesses address identified supply chain constraints, strengthen supplier readiness, improve production capability, and expand participation in strategically important supply chains. ADDITIONAL INFORMATION: Please register for the July 14th webinar on this NOFO: Microsoft Virtual Events Powered by Teams Within 5-6 days after the completion of this webinar, the recording will be available here: https://sba.box.com/s/4vsc6907qi9ju2od6x3dj2pg2qesnsnp

The purpose of this funding opportunity is to support the implementation and rigorous evaluation of existing Kinship Navigator Programs (KNPs). The goal is to increase the number of programs that qualify for federal Title IV-E Kinship Navigator funding by building strong evidence of improved outcomes for kinship caregivers and the children in their care. Strengthening the evidence base will position more programs for review by the Title IV-E Prevention Services Clearinghouse. This opportunity is intended for states and tribal communities that are not currently operating a Title IV-E Kinship Navigator Program.To achieve this goal, projects will focus on the following objectives: Administering KNP services, Collaborative planning, Evaluating the KNP, Complete a final evaluation report that demonstrates positive outcomes for kinship families.

The Delta States Rural Development Network Program supports support the planning, development, and implementation of integrated health care networks that collaborate in order to (i) achieve efficiencies; (ii) expand access to, coordinate, and improve the quality of basic health care services and associated health outcomes in rural areas within the eight rural Mississippi Delta Region states (Alabama, Arkansas, Illinois, Kentucky, Louisiana, Mississippi, Missouri, and Tennessee); and (iii) strengthen the rural health care system as a whole.

This Notice of Funding Opportunity (NOFO) supports strengthening country systems to detect, notify, and respond to outbreaks in alignment with the 7-1-7 target. Activities under this award are intended for implementation outside the United States and its territories. Building on previous outbreak experience and other international health emergencies, this NOFO advances American interests by reinforcing systems that protect both the United States and recipient nations. Activities focus on improving early detection of biological threats, timely notification across sectors and borders, and effective response to contain outbreaks before they spread. Efforts include strengthening surveillance, expanding laboratory readiness, enhancing information flows, and improving response operations to reduce health and economic effects. These activities emphasize burden sharing, accountability, and efficiency to ensure benefits to Americans at home and abroad, while supporting recipient nations in achieving long-term self-reliance and stability.

This Notice of Funding Opportunity (NOFO) seeks to build upon activities funded by CDC to support Global Health Security (GHS) in the Democratic Republic of Congo through implementation of programs and activities that focus on protecting and improving health globally through partnerships with Ministries of Health and other governmental institutions. The main outcomes of this NOFO are the following: (1) Improve prevention of avoidable epidemics including naturally occurring outbreaks and intentional or accidental releases of dangerous pathogens; (2) Improve ability to rapidly detect threats early, including detecting, characterizing, and reporting emerging public health threats;(3) Improve capacity of rapidly and effectively responding to infectious diseases and public health threats of international concern.

For over forty years, the U.S. Centers for Disease Control and Prevention (CDC) has partnered with the Government of Kenya (GoK) to protect the health of the Kenyan people and strengthen health systems. The United States Government remains the largest investor in Kenya"s health sector. This investment includes PEPFAR (President"s Emergency Plan for AIDS Relief), GHS (Global Health Security), Malaria, TB, Immunizations and Influenza. This Notice of Funding Opportunity (NOFO) seeks to build upon activities funded by CDC to support USG global health priorities in Kenya through implementation of programs and activities that focus on strengthening public health programs. After five years of implementing and strengthening global health security systems, the USG will continue to advance strategies to prevent, detect, and respond to public health threats. This NOFO"s main outcomes are to: 1) Improve prevention of avoidable epidemics including naturally occurring outbreaks and intentional or accidental releases of dangerous pathogens, 2) Improve ability to rapidly detect threats early, including detecting, characterizing, and reporting emerging biological threats, 3) Respond rapidly and effectively to public health threats of international concern, 4) Strengthen implementation science programs and platforms to improve health outcomes.

This Notice of Funding Opportunity (NOFO) seeks to build upon activities funded by CDC to support Global Health Security (GHS) through implementation of programs and activities that focus on protecting and improving health globally through partnerships with Ministries of Health and other governmental institutions. This NOFO will build on lessons learned from the global COVID outbreak and other significant public health events. After ten years of implementing and strengthening global health security systems, the U.S. Government (USG) will continue to advance strategies to prevent, detect, and respond to public health threats. This NOFO's main outcomes are to: 1) Improve prevention of avoidable epidemics including naturally occurring outbreaks and intentional or accidental releases of dangerous pathogens; 2) Improve ability to rapidly detect threats early, including detecting characterizing, and reporting emerging biological threats; 3) Responding rapidly and effectively to public health threats of international concern.

The purpose of this NOFO is to continue strengthening Uganda"s capacities for rapid detection and effective and efficient response to health threats. The focus of this NOFO is based on gaps outlined by the 2023 Joint External Evaluation of Uganda"s Global Health Security capacities including but not limited to surveillance, laboratory, rapid response, and countermeasures for priority human and zoonotic diseases, water- multi-hazard multi-sectoral preparedness in connection with Uganda"s National Action Plan for Health Security. Support national legislation for, and operationalization of functional, real-time funding for health emergencies - establishing a national border health program-rolling out a functional electronic platform expanding the National Integrated Surveillance System (NISS) linking surveillance, laboratory, notification, emergency responses, reporting, and workforce tracking data related to human and zoonotic priority diseases.

The NIH Director"s New Innovator Award supports early-stage investigators of exceptional creativity who propose bold and highly innovative research projects with the potential to produce a major impact on broad, important areas relevant to the mission of NIH. Applications in any area within the biomedical sciences are welcome; topics may involve basic, translational, or clinical research. The NIH Director's New Innovator Award complements other ongoing efforts by NIH and its Institutes and Centers to fund early-stage investigators. The NIH Director"s New Innovator Award is a component of the High-Risk, High-Reward Research (HRHR) program of the NIH Common Fund.

The Administration for Children and Families, Administration on Children, Youth and Families, Family and Youth Services Bureau announces the availability of funds under the Sexual Risk Avoidance Education (SRAE) Program. The purpose of the SRAE Program is to fund projects to implement sexual risk avoidance education that teach participants how to voluntarily refrain from non-marital sexual activity. The services are targeted to participants that reside in areas with high rates of teen births and/or are at greatest risk of contracting sexually transmitted infections (STIs). The goals of SRAE are to empower participants to make healthy decisions, and provide tools and resources to prevent pregnancy, STIs, and youth engagement in other risky behaviors. Successful applicants are expected to submit program plans that agree to: 1) use medically accurate information referenced to peer-reviewed publications by education, scientific, governmental or health organizations; 2) implement sexual risk avoidance curricula and/or strategies with an evidence-based approach to integrate research findings with practical implementation that aligns with the needs and desired outcomes for the intended audience; and 3) teach the benefits associated with self-regulation, success sequencing for poverty prevention, healthy relationships, goal setting, and resisting sexual coercion, dating violence, and other youth risk behaviors such as underage drinking or illicit drug use without normalizing teen sexual activity.

The Title V Competitive SRAE program competitively funds projects to implement sexual risk avoidance education that teaches youth ages 10-19 how to voluntarily refrain from non-marital sexual activity. Projects must: 1) use medically accurate information referencing peer-reviewed publications by educational, scientific, governmental, or health organizations; 2) implement an evidence-based approach integrating research findings with practical strategies that align with the needs and desired outcomes for the intended audience; 3) teach the benefits associated with personal responsibility, self-regulation, goal setting, healthy decision making, and a focus on the future; 4) discourage sexual coercion, dating violence, and other youth risk behaviors such as underage drinking or illicit drug use; 5) be culturally appropriate, recognizing the experiences of youth from diverse communities, backgrounds, and experiences; 6) normalize avoiding non-marital sexual activity; and 7) be age-appropriate. This opportunity supports the development and implementation of such projects in states that do not accept FY 2026 allocations for Title V State SRAE.

The Blueprint Neurotherapeutics Network (BPN) invites applications from neuroscience investigators seeking support to advance their small molecule drug discovery and development projects into the clinic. Participants in the BPN are responsible for conducting all studies that involve disease- or target-specific assays, models, and other research tools and receive funding for all activities to be conducted in their own laboratories. In addition, applicants will collaborate with NIH-funded consultants and can augment their project with NIH contract research organizations (CROs) that specialize in medicinal chemistry, pharmacokinetics, toxicology, formulations development, chemical synthesis including under Good Manufacturing Practices (GMP), and Phase I clinical testing. Projects can enter either at the Discovery stage, to optimize promising hit compounds through medicinal chemistry to the Development stage, to advance a single development candidate through Investigational New Drug (IND)-enabling toxicology studies and phase I clinical testing. Alternatively, projects can enter at the Development stage and progress in a shorter period to IND enabling toxicology studies and phase I clinical testing. BPN awardee Institutions retain their assignment of IP rights and gain assignment of IP rights from the BPN contractors (and thereby control the patent prosecution and licensing negotiations) for drug candidates developed in this program.

Leveraging foreign assistance from the Pax Fund, this NOFO launches the Pax Silica Artificial Intelligence (AI) Assistance Project—a historic first-of-its-kind programmatic initiative to strengthen global AI supply chain security by creating a trusted supply chain credentialing and provenance platform to secure the AI supply chain in partner countries and economies. This NOFO seeks to fund the establishment of a Silicon Highway: a digital-physical corridor that accelerates logistics and compliance operations among partner countries with cryptographic cargo verification, AI-expedited risk assessment, and pre-approved expedited processing early in the supply chain. The Department maintains its rights of use to intangible property created under this project per 2 CFR 200.315.

Leveraging foreign assistance from the Pax Fund, this NOFO launches the Pax Silica Artificial Intelligence (AI) Assistance Project—a historic first-of-its-kind programmatic initiative to strengthen global AI supply chain security by creating a trusted supply chain credentialing and provenance platform to secure the AI supply chain in partner countries and economies. This NOFO seeks to fund the establishment of a Silicon Highway: a digital-physical corridor that accelerates logistics and compliance operations among partner countries with cryptographic cargo verification, AI-expedited risk assessment, and pre-approved expedited processing early in the supply chain. The Department maintains its rights of use to intangible property created under this project per 2 CFR 200.315.

Federal Awarding Agency Name: U.S. Department of Agriculture (USDA), Natural Resources Conservation Service (NRCS), Commodity Credit Corporation (CCC) Funding Opportunity Title: Regional Conservation Partnership Program (RCPP) Classic for federal fiscal year (FY) 2026. Funding Opportunity Number: USDA-NRCS-NHQ-RCPP-Classic-26-NOFO0001450 Assistance Listing: 10.932, Regional Conservation Partnership Program (RCPP) Due Date: NRCS must receive proposals by 4:59 p.m. Eastern Time on August 24, 2026. Note: The RCPP Classic and Alternative Funding Arrangement (AFA) FY 2026 notices of funding opportunity (NOFO) will run concurrently. For information on AFA proposals please see Funding Opportunity Number USDA-NRCS-NHQ-RCPP-AFA-26-NOFO0001451. The RCPP promotes the coordination of NRCS conservation activities with partners that offer value-added contributions to expand our ability to address on-farm, watershed, and regional natural resource concerns. Through the RCPP, NRCS seeks to co-invest with partners to implement projects that provide solutions to conservation challenges thereby measurably improving the resource concerns they seek to address. RCPP promotes collaboration with partners, stakeholders, and various communities, which is paramount to achieving equity in NRCS programs and services. Partners use this notice to propose projects that improve natural resources in one or more states or focus on priority concerns in NRCS-designated Critical Conservation Areas (CCAs). NRCS works with these partners to plan and carry out projects on farms, ranches and private forest land. Thr...

Federal Awarding Agency Name: U.S. Department of Agriculture (USDA), Natural Resources Conservation Service (NRCS), Commodity Credit Corporation (CCC) Funding Opportunity Title: Regional Conservation Partnership Program (RCPP) Alternative Funding Arrangements (AFA) for Federal fiscal year (FY) 2026   Funding Opportunity Number: USDA-NRCS-NHQ-RCPP-AFA-26-NOFO0001451   Assistance Listing: 10.932, Regional Conservation Partnership Program (RCPP)   Due Date: NRCS must receive proposals by 4:59 p.m. Eastern Time on August 24, 2026.   Note: The RCPP AFA and Classic FY 2026 notices of funding opportunity (NOFO) will run concurrently. For information on Classic proposals please see USDA-NRCS-NHQ- RCPP-Classic-26-NOFO0001450. The RCPP promotes the coordination of NRCS conservation activities with partners that offer value-added contributions to expand our ability to address on-farm, watershed, and regional natural resource concerns. Through the RCPP, NRCS seeks to co-invest with partners to implement projects that provide solutions to conservation challenges thereby measurably improving the resource concerns they seek to address. RCPP promotes collaboration with partners, stakeholders, and various communities, which is paramount to achieving equity in NRCS programs and services. Partners use this notice to propose projects that improve natural resources in one or more states or focus on priority concerns in NRCS-designated Critical Conservation Areas (CCAs). NRCS works with these partners to plan and carry out projects on farms, ranches and private forest land. Through the program,....

The Office of Community Oriented Policing Services (COPS) is the component of the U.S. Department of Justice responsible for advancing the practice of community policing and the Administration’s priority of Making America Safe Again by supporting the nation’s state, local, territorial and Tribal law enforcement agencies through information and grant resources. Community Policing Development (CPD): Law Enforcement Products and Resources funds are used to develop products and resources to provide guidance on promising practices; develop and test innovative strategies; build knowledge about effective practices and outcomes; and support new, creative approaches to preventing crime and promoting safe communities and a positive image of policing. The COPS Office seeks to enhance community policing development through this NOFO in the following two funding categories: Category 1: FY26 Community Policing Development – Law Enforcement Products and Resources The COPS Office CPD: Law Enforcement Products and Resources program provides funding for the development of resources on law enforcement topics, specifically designed for national distribution, that offer creative ideas to advance crime fighting and community policing through common sense policing practices and initiatives. Any proposed product or resource should be directly in support of the advancement of community policing through common sense policing strategies and practices. Category 2: FY26 Community Policing Development – COPS Training Portal The COPS Office CPD COPS Training Portal funds are used to deploy the COPS Offic...

The Office of Community Oriented Policing Services (COPS) is the component of the U.S. Department of Justice responsible for advancing the practice of community policing and the Administration’s priority of Making America Safe Again by supporting the nation’s state, local, territorial and Tribal law enforcement agencies through information and grant resources. The FY26 Collaborative Reform Initiative (CRI) program funding seeks to provide best practices of law enforcement agencies and the many ways they are protecting Americans, enhance officer safety and wellness, build agencies’ capacity for self-improvement and effectiveness, and promote community policing practices nationwide. This funding opportunity has two program subcategories of which applicants may apply for funding: Category 1: Collaborative Reform Initiative Technical Assistance Center (CRI-TAC). Since 2017, CRI-TAC has provided a wide array of TA services using a “by the field, for the field” approach. The CRI-TAC process is agency-driven and offers customizable, short-term technical assistance on more than 60 topics. Category 2: Collaborative Reform Initiative Critical Response. The Critical Response program is designed to provide targeted TA to law enforcement agencies experiencing high-profile events, major incidents, or sensitive issues of varying need. Critical Response is highly customizable and provides flexible assistance to law enforcement agencies in a variety of ways, including after-action reviews; peer-to-peer exchanges; targeted in-depth review, analysis, recommendations, and assessments; and faci...

The Office of Community Oriented Policing Services (COPS) is the component of the U.S. Department of Justice responsible for advancing the practice of community policing and the Administration’s priority of Making America Safe Again by supporting the nation’s state, local, territorial and Tribal law enforcement agencies through information and grant resources. The FY26 Collaborative Reform Initiative (CRI) Organizational Assessment and Enhanced Training program funding opportunity to identify and implement organizational improvements aligned with the principles of community policing to law enforcement agencies through assessments, technical assistance and enhanced training. The Enhanced Training program offers a suite of innovative new on-line enhanced training experiences for law enforcement professionals nationwide that focus on implementing organizational and operational improvements and measuring outcomes in short amounts of time (between three and six months). They are conducted through a series of regularly scheduled virtual trainings with specific projects developed by participants for completion. The key features of the enhanced training experience include training in cohorts, flexible scheduling, blended learning, and continuous access to trainers and subject matter experts throughout the training period. Enhanced training courses are designed to maximize outcomes, implementation of new concepts, meaningful participation, and sustainability.

The United States Marine Highway Program (USMHP), codified at 46 U.S.C. 55601, was originally established by Section 1121 of the Energy Independence and Security Act of 2007 to reduce landside congestion through the designation of Marine Highway Routes. The USMHP statute authorizes the U.S. Department of Transportation (“Department” or “DOT”) to make grants to implement Projects or components of Projects that 1) provide a coordinated and capable alternative to landside transportation; mitigate or relieve landside congestion; promote Marine Highway Transportation; or use vessels documented under 46 U.S.C. chapter 121; and 2) develop, expand, or promote Marine Highway Transportation or shipper use of Marine Highway Transportation

The NIH Director"s Transformative Research Award supports individual scientists or groups of scientists proposing bold, groundbreaking, exceptionally innovative, original, and/or unconventional research with the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies. Applications in any area within the biomedical sciences are welcome; topics may involve basic, translational, or clinical research. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in a broad area of relevance to the NIH. The NIH Director"s Transformative Research Award is a component of the High-Risk, High-Reward Research (HRHR) program of the NIH Common Fund.

This Funding Opportunity Announcement (FOA) encourages grant applications for Biomedical Technology Resource Centers (BTRCs). BTRCs are national resource centers for conducting research and development on new technologies that are driven by the needs of basic, translational, and/or clinical researchers. BTRCs also make their technologies available to other investigators, train members of the research community in the use of the technologies, and disseminate the technologies broadly.

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) invites applications for projects to expand, improve, or transform the utility of mammalian cancer and tumor models for translational research. With this NOFO, the NCI intends to encourage submission of projects devoted to demonstrating that mammalian models or their derivatives used for translational research are robust representations of human biology, are appropriate to test questions of clinical importance, and provide reliable information for patients' benefit. These practical goals contrast with the goals of many mechanistic, NCI-supported R01 projects that employ mammals, or develop and use mammalian cancer models, transplantation tumor models, or models derived from mammalian or human tissues or cells for hypothesis-testing, non-clinical research. Among many other possible endeavors, applicants in response to this FOA could propose demonstrations of how to overcome translational deficiencies of mammalian oncology models, define new uses of mammalian models or their genetics for unexplored translational challenges, advance standard practices for use of translational models, test approaches to validate and credential models, or challenge current practices for how models are used translationally

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits applications for identification of small molecules that function to elucidate the biology of disease as chemical probes or function as agonists or antagonists of disease target(s) for therapy or immunotherapy. The NOFO is intended to support discovery research for the identification of validated hits relevant to health-related outcomes of participating NIH Institutes. Stages of discovery research covered by this NOFO include: 1) assay development for specific biological targets and disease mechanisms relevant to the mission of participating NIH Institutes with the intent to screen for small molecule compounds that show potential as probes for use in advancing knowledge about the known targets, identifying new targets, or as pre-therapeutic leads; 2) screen implementation high throughput target-focused approaches or moderate throughput phenotypic- and fragment-based approaches to identify initial screening hits; 3) hit validation, including implementation of secondary assays that are orthogonal to the primary assay, advanced cheminformatics analysis and initial medicinal chemistry inspection to prioritize the hit set, and follow-up assays to characterize mode and mechanism of action of the validated hits; 4) hit-to-lead optimization, including SAR to optimize target engagement, selectivity and to minimize chemical liabilities, ADME, PK and PD studies, and, if appropriate, in vivo modeling to test efficacy or biological effects.